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Pyrazolyl‐Benzoxazinone Derivatives as Dual Hsp Inhibitors in Human Breast Cancer
(2022)
Heat Shock Proteins (Hsps) play major role on the onset of several cancers. Metabolic rates of cancer cells are higher compared to that of untransformed cells. This accelerated rate force functional substrate proteins to ...
The role of cytokeratin 19 levels in the determination of endometriosis stages
(2022)
Objective/Aim: Endometrisosis, one of the most common gynecological disease, is characterized by
the presence of endometriotic tissue outside of uterine cavity. The development and the validation
of a simple blood ...
A new method for synthesis of carbon nanoparticle and its applications
(2022)
In the present study, we synthesized carbon nanoparticles with a different method using chi tosan, a natural polymer. As a result, carbon nanomaterials were diffused directly through the
intestinal membrane, and carbon ...
Determination of sunset yellow, allura red, and fast green using a novel magnetic nanoadsorbent modified with Elaeagnus angustifolia based on magnetic solid-phase extraction by HPLC
(UNIV SAO PAULO, CONJUNTO QUIMICAS, 2022)
Sunset yellow (SY), allura red (AR) and fast green (FG) are frequently used in commercial food products, although they are considered to be hazardous to public health due to their toxic efficacy and high exposure risk ...
Evaluation of the effects of newly synthesized metallophthalocyanines on breast cancer cell lines with photodynamic therapy
(2022)
In this study, the new phthalonitrile derivative 3-(4-(3-oxobutyl)phenoxy)phthalonitrile (1) and its non peripheral metallophthalocyanine derivatives [zinc (2), copper (3), cobalt (4), manganese (5), gallium (6),
and ...
Investigation of possible associations between tryptophan/kynurenine status and FOXP3 expression in colorectal cancer
(2022)
Tryptophan metabolism in the tumor microenvironment exerts immunosuppressive effects by affecting
the anti-tumor functions of immune cells. The immunosuppressive roles of tryptophan and tryptophan
metabolites and their ...
Possible effects of clinoptilolite on small intestinal ischemia-reperfusion injury caused by experimental mesenteric artery occlusion
(2022)
Objectives: Mesenteric ischemia is a surgical emergency caused by poor blood supply to the intestines. In ischemia,the decrease in blood flow to the tissue causes acidosis and cell death through anaerobic metabolism. ...
Design, synthesis and in vitro antiproliferation activity of some 2-aryl and -heteroaryl benzoxazole derivatives
(2022)
Background: Phortress produces reactive electrophilic metabolites that form DNA adducts only in
sensitive tumor cells. The authors converted the 2-phenylbenzothiazole nucleus in phortress to 2-
aryl and -heteroaryl ...
circRNAs in drug resistance of breast cancer
(2022)
Abstract: Breast cancer (BC) is the most common heterogeneous disease in women and one of the leading causes of cancer-related death. Surgery, chemotherapy, radiotherapy, hormone, and targeted therapy are the gold standards ...
Synthesis, Biological Evaluation and In Silico Studies of Some 2‐Substituted Benzoxazole Derivatives as Potential Anticancer Agents to Breast Cancer
(2022)
In an attempt to develop potent and selective anticancer agents, some 5- or 6- and N-substituted benzoxazol-2-carbox amide derivatives were designed, synthesized, and evaluated for their cyclooxygenase inhibitory, antioxidant, ...