Immunologic and biochemical factors in hyperemesis gravidarum with or without hyperthyroxinemia
Abstract
Objective: This study was set up to investigate the relationship between immune process and high levels of human chorionic gonadotropin-beta (beta hCG) in hyperemesis patients with or without hyperthyroxinemia. Methods: beta hCG, immune parameters and thyroid related hormones were assayed in hyperemesis patients and in controls. Results: Mean serum beta hCG, fT4 and TSH levels were significantly higher in hyperemesis patients than in controls (p < 0.01, p < 0.01, p < 0.05, respectively). Further, immune parameters regarding IgG, IgM, C3 C4 and lymphocyte count were significantly higher in patients than in controls (p < 0.05, p < 0.01, p < 0.01, p < 0.05, p < 0.01, respectively). In hyperemesis patients with hyperthyroxinemia, mean serum beta hCG, IgG and IgM were significantly higher than in hyperemesis women without hyperthyroxinemia (p < 0.001, p < 0.05, p < 0.05, respectively). beta hCG was positively correlated with fT4 (r = 0.45, p < 0.05), with lymphocyte count (r = 0.47, p < 0.01), with IgM (r = 0.38, p < 0.05) and with C3 (r = 0.40, P < 0.05) in hyperemesis patients. A negative correlation between beta hCG and ISH (r = -0.43, p < 0.05) was noted in the hyperemesis group. Free T-4 showed a positive association to IgM (r = 0.49, p < 0.01), to IgG (r = 0.40, p < 0.05), to lymphocyte count (r = 0.45, p < 0.05). Conclusion: Immunologic activity in pregnancy may have an effect or role on the stimulatory mechanism of beta hCG in hyperemesis patients with or without hyperthyroxinemia.
Source
GYNECOLOGIC AND OBSTETRIC INVESTIGATIONVolume
47Issue
4Collections
- Makale Koleksiyonu [5200]
- Makale Koleksiyonu [5745]
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