dc.contributor.author | Leylek, OA | |
dc.contributor.author | Cetin, A | |
dc.contributor.author | Toyaksi, M | |
dc.contributor.author | Erselcan, T | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T10:38:45Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T10:38:45Z | |
dc.date.issued | 1996 | |
dc.identifier.issn | 0020-7292 | |
dc.identifier.uri | https://dx.doi.org/10.1016/0020-7292(96)02737-3 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/11875 | |
dc.description | WOS: A1996VP67900006 | en_US |
dc.description | PubMed ID: 8910080 | en_US |
dc.description.abstract | Objective: To evaluate the hormonal and hematologic parameters of 24 patients with hyperemesis gravidarum without evidence of thyroid disease compared with matched controls. Methods: Twenty-four pregnant women with hyperemesis and 20 control subjects were included in this study. A prospective comparison of hormonal milieu of hCG and thyroid function was performed. Results: Mean serum hCG, ft3, and fT4 levels of patients were significantly higher than those of controls (P <0.007), while there was no statistically significant difference in terms of TSH. Serum hCG correlated negatively with TSH and positively with ft3 and fT4 in the patient group (r=0.66, r=0.70, r=0.85; P <0.05, respectively), while there was no relationship between hCG and thyroid functions in controls (r<0.25). The lymphocyte count of patients was significantly higher than that of controls (P <0.007), while there were no statistically significant differences in the overall white blood count and the granulocyte count (P >0.007). The lymphocyte count correlated positively with serum hCG, fT4 and fT3, and negatively with TSH in the patient group (r=0.73, r=0.72, r=0.64 and r=-0.63; P <0.05, respectively), while there was no relationship between lymphocyte count and serum hCG, fT4, fT3 and TSH in controls (r <0.25). Conclusions: Maternal immune recognition of the conceptus and immune response, hypothetically, may be related to the high level of hCG and/or fT4. Patients who Rave hyperthyroidism in early pregnancy should be assessed for transient hyperthyroidism as it relates to hyperemesis gravidarum. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | ELSEVIER SCI IRELAND LTD | en_US |
dc.relation.isversionof | 10.1016/0020-7292(96)02737-3 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | hyperemesis gravidarum | en_US |
dc.subject | human chorionic gonadotropin | en_US |
dc.subject | thyroid function | en_US |
dc.subject | immune system | en_US |
dc.title | Hyperthyroidism in hyperemesis gravidarum | en_US |
dc.type | article | en_US |
dc.relation.journal | INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS | en_US |
dc.contributor.department | CUMHURIYET UNIV,SCH MED,DEPT NUCL MED,SIVAS,TURKEY | en_US |
dc.contributor.authorID | Cetin, Ali -- 0000-0002-5767-7894 | en_US |
dc.identifier.volume | 55 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.endpage | 37 | en_US |
dc.identifier.startpage | 33 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |