Nanoparticles with PDT and PTT synergistic properties working with dual NIR-light source simultaneously
Abstract
A non-toxic nano system using a cleverly designed dual light can be an important treatment strategy in
cancer therapy. Here, we propose a unique concept of synergistic non-toxic nanoplatform, which
operates with dual light. An apoferritin nano-platform whose surface was modified with Verteporfin
(Visudyne®) and with ultra-small CuS nanoparticles in the center demonstrated the synergistic effect of
photodynamic therapy (PDT) and photothermal therapy (PTT). The synergistic effect of PDT and PTT
were achieved with 808 nm laser light and 690 nm LED light, respectively. These results not only give
a new horizon to multifunctional nanostructures for biological applications but also show a new way to
design the novel PDT and PTT agents.