dc.contributor.author | TUTAR, UĞUR | |
dc.contributor.author | GEZEGEN, HAYREDDİN | |
dc.contributor.author | CEYLAN, HEPOKUR | |
dc.contributor.author | TÜZÜN, GAMZE | |
dc.contributor.author | ATİOĞLU, ZELİHA | |
dc.contributor.author | AKKURT, MEHMET | |
dc.date.accessioned | 2022-05-13T08:15:55Z | |
dc.date.available | 2022-05-13T08:15:55Z | |
dc.date.issued | 2021 | tr |
dc.identifier.citation | Gezegen, H., Tutar, U., Hepokur, C., Tüzün, G., Atioğlu, Z., & Akkurt, M. (2021). Michael/Michael Addition Cascade of 2‐Benzylidene‐1‐indanones with Chalcones: Synthesis and Biological Evaluations of Novel Polycyclic Compounds. ChemistrySelect, 6(36), 9625-9631. | tr |
dc.identifier.uri | https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/slct.202102738 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/12991 | |
dc.description.abstract | A series of novel racemic 2-aryloyl-1,3-diaryl-2,3,3a,8a-tetrahydrocyclopenta[
a]inden-8(1H)-one derivatives were synthesized
from KOtBu mediated Michael/Michael addition reaction of 2-
benzylidene-1-indanones with chalcones in high yields. This
method provides an efficient route for the synthesis of a new
class of polycyclic compounds have five stereo centers. The
obtained polycyclic compounds were evaluated for the antimicrobial
and anticancer activities against fifteen microorganism
and three cell lines. The compound 3r have the best
activity value against the cells (MCF-7 IC50=18.01�0.39 μg/
mL) (MDA-MB- 231 IC50=18.78�1.75 μg/mL) (MCF-10 A IC50=
31.31�0.05 μg/mL). | tr |
dc.language.iso | eng | tr |
dc.publisher | WİLLEY ONLİNE LİBRARY | tr |
dc.rights | info:eu-repo/semantics/closedAccess | tr |
dc.subject | Chalcones | tr |
dc.subject | Polycyclic compounds | tr |
dc.subject | Antimicrobial | tr |
dc.title | Michael/Michael Addition Cascade of 2-Benzylidene-1- indanones with Chalcones: Synthesis and Biological Evaluations of Novel Polycyclic Compounds | tr |
dc.type | article | tr |
dc.relation.journal | ChemistrySelect | tr |
dc.contributor.department | Eczacılık Fakültesi | tr |
dc.contributor.authorID | 0000-0002-8058-0994 | tr |
dc.identifier.volume | 2021 | tr |
dc.identifier.issue | 6 | tr |
dc.identifier.endpage | 9631 | tr |
dc.identifier.startpage | 9625 | tr |
dc.relation.publicationcategory | Uluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanı | tr |