Synthesis, characterization, antimicrobial and antibiofilm activity, and molecular docking analysis of NHC precursors and their Ag-NHC complexes†
Göster/ Aç
Tarih
2021Yazar
TUTAR, UĞURÜSTÜN, ELVAN
ŞAHİN, NESLİHAN
ÇELİK, CEM
ÖZDEMİR, NAMIK
GÜRBÜZ, NEVİN
ÖZDEMİR, İSMAİL
Üst veri
Tüm öğe kaydını gösterKünye
Üstün, E., Şahin, N., Çelik, C., Tutar, U., Özdemir, N., Gürbüz, N., & Özdemir, İ. (2021). Synthesis, characterization, antimicrobial and antibiofilm activity, and molecular docking analysis of NHC precursors and their Ag-NHC complexes. Dalton Transactions, 50(42), 15400-15412.Özet
Microorganisms attach to surfaces and interfaces and form biofilms which create a sheltered area for host
cell response. Therefore, biofilms provide troubles in fields such as medicine, food, and pharmaceuticals.
Inhibition of formation of biofilms through hindering of quorum sensing could be a method for the production of new generation antibiotics. In this study, four new benzimidazole type NHC precursors (1-allyl3-benzyl-5,6-dimethylbenzimidazolium chloride, 1-allyl-3-(2,4,6-trimethylbenzyl)-5,6-dimethylbenzimidazolium chloride, 1-allyl-3-(2,3,5,6-tetramethylbenzyl)-5,6-dimethylbenzimidazolium chloride,
and 1-allyl-3-(2,3,4,5,6-pentamethylbenzyl)-5,6-dimethylbenzimidazolium chloride and Ag-NHC complexes of these molecules were synthesized and characterized by elemental analysis, FT-IR spectroscopy,
1
H, and 13C{1
H} NMR spectroscopy, LC-MS, and single crystal crystallography. Antimicrobial and biofilm
formation inhibition activities of the molecules were evaluated. In addition, the activities of the molecules
were examined in detail by molecular docking analysis. According to the results obtained, higher activity
was achieved with the complex molecules when compared with the benzimidazole derivative ligands.
Kaynak
Dalton TransactionsCilt
2021Sayı
50Bağlantı
https://pubs.rsc.org/en/content/articlelanding/2021/dt/d1dt02003j/unauthhttps://hdl.handle.net/20.500.12418/12993