dc.contributor.author | TAŞ Ayça | |
dc.contributor.author | GÜMÜŞ Erkan | |
dc.contributor.author | ÖZMEN Esma | |
dc.contributor.author | ERDOĞAN Haydar | |
dc.contributor.author | SİLİĞ Yavuz | |
dc.date.accessioned | 2022-05-13T11:05:04Z | |
dc.date.available | 2022-05-13T11:05:04Z | |
dc.date.issued | 2021 | tr |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/13040 | |
dc.description.abstract | Objectives: The aim of this study was to investigate BAP1,
OGT and YY1 genes and protein levels in 12 samples
(8 males, 4 females) of eyelid tumor tissue with basal cell
carcinoma (BCC) and 12 normal control subjects (8 males, 4
females).
Methods: The expression levels of these genes were
determined with RT-PCR and the protein levels and
expression using ELISA and IHC methods, respectively.
Results: In RT-PCR analysis, statistically significant
upregulated expression was determined of 1.84-fold of
BAP1, 2.85-fold of OGT and 3.06-fold of YY1 genes (p < 0.05).
In the patient group, compared to the control group, there
was a similar statistically significant strong correlation
between the proteins (BAP1 and YY1; r = 0.850, BAP1 and
OGT; r = 0.811, OGT and YY1; r = 0.755) (p < 0.05). In the
ELISA and IHC analysis methods, a significant increase in
BAP1 and YY1 protein expression levels was observed
compared to the control group (p < 0.05).
Conclusions: The study results demonstrated that BAP1
and YY1 genes and protein levels were upregulated in
eyelid tumor tissue with BCC. | tr |
dc.language.iso | eng | tr |
dc.publisher | De Gruyter | tr |
dc.relation.isversionof | https://doi.org/10.1515/tjb-2021-0160 | tr |
dc.rights | info:eu-repo/semantics/openAccess | tr |
dc.subject | BAP1; basal cell carcinoma; expression; eyelid; OGT; tumor; YY1 | tr |
dc.title | Expression levels of BAP1, OGT, and YY1 genes in patients with eyelid tumors | tr |
dc.type | article | tr |
dc.relation.journal | Turkish Journal of Biochemistry | tr |
dc.contributor.department | Tıp Fakültesi | tr |
dc.contributor.authorID | 0000-0002-0562-7457 | tr |
dc.identifier.volume | 46 | tr |
dc.identifier.issue | 6 | tr |
dc.identifier.endpage | 719 | tr |
dc.identifier.startpage | 709 | tr |
dc.relation.publicationcategory | Uluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanı | tr |