In–Vitro Anticancer and Antibacterial Activities of Brominated Indeno[1,2-b]qinoline Amines Supported with Molecular Docking and MCDM
Citation
Ali Aydın,[a]SalihÖkten,*[b]SultanErkan,[c]MerveBulut,[d]EvrencanÖzcan,[d]AhmetTutar,[e]and TamerEren[d [a]Assoc.Prof. Dr. A. AydınDepartmentof BasicMedicalScience,Facultyof Medicine,BozokUniversity,Yozgat,Turkey [b]Assoc.Prof. Dr. S. ÖktenDepartmentof Mathsand ScienceEducation,Facultyof Education,KırıkkaleUniversity,Yahşihan,Kırıkkale,TurkeyE-mail:sokten@gmail.comsalihokten@kku.edu.tr [c]Dr. SultanErkanDepartmentof Chemistry,Facultyof Science,SivasCumhuriyetUniversity,Sivas,Turkey [d]M. Sc. M. Bulut,Assoc.Prof. Dr. E. Özcan,Prof. Dr. T. ErenDepartmentof IndustrialEngineering,Facultyof Engineeringand Architecture,KırıkkaleUniversity,Yahşihan,Kırıkkale,Turkey [e]Prof. Dr. A. TutarFacultyof Art and Science,Departmentof Chemistry,SakaryaUniversity,Serdivan,Sakarya,TurkeyAbstract
The present study describes mono substituted indeno[1,2-b]quinolines (3 a–c and 5) have much more antiproliferative potentials than positive controls against A549, HeLa, MCF7 and Hep3B cell lines (IC50 values 1.1–29.6 μg/mL) and show similar cytotoxicity (14.3 % to 19.8 %) to cells such as controls. Moreover, the mono substituted indeno[1,2-b]quinoline amines (3 a–c and 5) exhibit significant antimicrobial activity with MIC values between 15.62 μg/mL and 250 μg/mL. The compounds can also bind to DNA in the groove binding mode with a binding constant range of 1.1×103–1.1×105 M−1. The anticancer and antibacterial properties of compounds were confirmed with the molecular docking simulation for their pharmacokinetic. As a result, the preliminary experimental data and a multi-criteria decision-making methodology (MCDM) indicated that the mono substituted indeno[1,2-b]quinoline amine derivatives, especially 3 a and 5, exhibit effective pharmacological properties. parameters and their interaction with related cells at the molecular level.
Source
ChemistrySelectVolume
6URI
https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/slct.202004753https://hdl.handle.net/20.500.12418/13044