| dc.contributor.author | Taş, Ayça | |
| dc.contributor.author | Gümüş, Erkan | |
| dc.contributor.author | Özmen, Esma | |
| dc.contributor.author | Erdoğan, Haydar | |
| dc.contributor.author | Siliğ, Yavuz | |
| dc.date.accessioned | 2022-05-13T11:20:58Z | |
| dc.date.available | 2022-05-13T11:20:58Z | |
| dc.date.issued | 2021 | tr |
| dc.identifier.citation | Ayca Tas, Department of Nutrition and Diet,
Faculty of Health Sciences, Sivas Cumhuriyet University, 58140 Sivas,
Turkey, Phone: +90 3462580000, E-mail: aycatas@cumhuriyet.edu.tr.
https://orcid.org/0000-0002-7132-1325
Erkan Gumus, Department of Histology and Embryology, Faculty of
Medicine, Adnan Menderes University, Aydın, Turkey,
E-mail: erkangumus@yahoo.com.
https://orcid.org/0000-0001-6432-7457
Esma Ozmen, Department of Medical Biochemistry, Faculty of
Medicine, Nigde Omer Halis Demir University, Nigde, Turkey,
E-mail: ozmenesma07@gmail.com.
https://orcid.org/0000-0003-3223-6854
Haydar Erdogan, Department of Ophthalmology, Faculty of Medicine,
Sivas Cumhuriyet University, Sivas, Turkey,
E-mail: herdogan@cumhuriyet.edu.tr.
https://orcid.org/0000-0002-9337-6968
Yavuz Silig, Department of Medical Biochemistry, Faculty of Medicine,
Sivas Cumhuriyet University, Sivas, Turkey,
E-mail: ysilig@cumhuriyet.edu.tr.
https://orcid.org/0000-0002-0562-7457 | tr |
| dc.identifier.uri | https://hdl.handle.net/20.500.12418/13049 | |
| dc.description.abstract | Objectives: The aim of this study was to investigate BAP1,
OGT and YY1 genes and protein levels in 12 samples
(8 males, 4 females) of eyelid tumor tissue with basal cell
carcinoma (BCC) and 12 normal control subjects (8 males, 4
females).
Methods: The expression levels of these genes were
determined with RT-PCR and the protein levels and
expression using ELISA and IHC methods, respectively.
Results: In RT-PCR analysis, statistically significant
upregulated expression was determined of 1.84-fold of
BAP1, 2.85-fold of OGT and 3.06-fold of YY1 genes (p < 0.05).
In the patient group, compared to the control group, there
was a similar statistically significant strong correlation
between the proteins (BAP1 and YY1; r = 0.850, BAP1 and
OGT; r = 0.811, OGT and YY1; r = 0.755) (p < 0.05). In the
ELISA and IHC analysis methods, a significant increase in
BAP1 and YY1 protein expression levels was observed
compared to the control group (p < 0.05).
Conclusions: The study results demonstrated that BAP1
and YY1 genes and protein levels were upregulated in
eyelid tumor tissue with BCC. | tr |
| dc.language.iso | eng | tr |
| dc.publisher | De Gruyter | tr |
| dc.relation.isversionof | https://doi.org/10.1515/tjb-2021-0160 | tr |
| dc.rights | info:eu-repo/semantics/openAccess | tr |
| dc.subject | BAP1; basal cell carcinoma; expression; eyelid; OGT; tumor; YY1 | tr |
| dc.title | Expression levels of BAP1, OGT, and YY1 genes in patients with eyelid tumors | tr |
| dc.type | article | tr |
| dc.relation.journal | Turkish Journal of Biochemistry | tr |
| dc.contributor.department | Sağlık Bilimleri Fakültesi | tr |
| dc.contributor.authorID | 0000-0002-7132-1325 | tr |
| dc.identifier.volume | 46 | tr |
| dc.identifier.issue | 6 | tr |
| dc.identifier.endpage | 719 | tr |
| dc.identifier.startpage | 709 | tr |
| dc.relation.publicationcategory | Uluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanı | tr |
