Quinoline-fused both non-peripheral and peripheral ZnII and MgII phthalocyanines: Anti-cholinesterase, anti- α-glucosidase, DNA nuclease, antioxidant activities, and in silico studies
Date
08.04.2022Metadata
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Halise Yalazan1 | Burak Tüzün2 | Didem Akkaya3 | Burak Barut3 | Halit Kantekin1 | Sermet Yıldırmıs¸3 1Faculty of Sciences, Department of Chemistry, Karadeniz Technical University, Trabzon, Turkey 2Plant and Animal Production Department, Technical Sciences Vocational School of Sivas, Sivas Cumhuriyet University, Sivas, Turkey 3Faculty of Pharmacy, Department of Biochemistry, Karadeniz Technical University, Trabzon, TurkeyAbstract
Quinoline-fused ZnII (ZnPcp/ZnPcnp) and MgII (MgPcp/MgPcnp) phthalocyanines
with four 4-methylquinolin-2-ol (1) at non-peripheral or peripheral
positions of the phthalocyanine core have been synthesized via
cyclotetramerization of phthalonitrile derivatives (CNp/CNnp) in the presence
of zinc (II) and magnesium (II) metal ions in this study. After synthesis and
characterization processes, anti-cholinesterase, anti-α-glucosidase, DNA
nuclease, antioxidant activities, and in silico calculations of both peripheral
and non-peripheral ZnII and MgII phthalocyanines were investigated. The
inhibitory effects of metallated phthalocyanines on acetylcholinesterase, butyrylcholinesterase,
and α-glucosidase enzymes were tested by spectrophotometric
method. Theoretical methods are used to compare both the chemical
and biological activities of the studied phthalonitrile derivatives and metallated
phthalocyanine compounds.