dc.contributor.author | Taslimi, Parham | |
dc.contributor.author | Kocyigit, Umit M. | |
dc.contributor.author | Tüzün,Burak | |
dc.contributor.author | Kirici, Mahinur | |
dc.date.accessioned | 2023-04-12T05:36:53Z | |
dc.date.available | 2023-04-12T05:36:53Z | |
dc.date.issued | 04.10.2020 | tr |
dc.identifier.citation | Parham Taslimi, Umit M. Kocyigit, Burak Tüzün & Mahinur Kirici
To cite this article: Parham Taslimi, Umit M. Kocyigit, Burak Tüzün & Mahinur Kirici (2022)
Biological effects and molecular docking studies of Catechin 5-O-gallate: antioxidant,
anticholinergics, antiepileptic and antidiabetic potentials, Journal of Biomolecular Structure and | tr |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/13578 | |
dc.description.abstract | Gallocatechin gallate is a form of catechin and an ester of gallocatechin and gallic acid. This is an epimer
of the gallate epigallocatechin. In this study, the effect of this molecule, containing a biologically
active group, was investigated in terms of important metabolic enzymes (carbonic anhydrase isoenzymes
I and II (hCA I and II), achethylcholinesterase (AChE) and a-glycosidase (a-Gly) enzymes). The
molecular docking method used to compare the biological activities of the Catechin 5-O-gallate molecule
against enzymes was used. Afterwards, the ADME/T analysis was performed to investigate the
drug availability of the Catechin 5-O-gallate molecule and the parameters obtained from ADME/T analysis
were examined. Continuation of this study, for evaluating antioxidant and radical scavenging capacity
Catechin 5-O-gallate, cupric ion (Cu2þ) reduction capacity by CUPRAC method, Fe3þ-Fe2þ
reducing capacity, DPPH free radical clarifying (DPPH· ), ABTS radical clarifying (ABTS þ) were performed
separately and during the study, trolox, a-tocopherol BHT and BHA were used as the reference
antioxidant compound. Comparisons were applied with the four standard substances.
Abbreviations: ADME: absorption, distribution, metabolism and excretion; ACR: acarbose; AZA: acetazolamide;
AChE: achethylcholinesterase; ABTS: 2, 2’-azino-Bis-3-ethylbenzothiazoline-6-sulfonic acid
(biochemical reagent); a-Gly: a-glycosidase; BHA: butylated hydroxyanisole; BHT: butylated hydroxytoluene;
BChE: butyrylcholinesterase; CA: carbonic anhydrase; CUPRAC: cupric reducing antioxidant capacity;
DPPH: 2,2-diphenyl-1-picrylhydrazyl; EGCG: gallate epigallocatechin; GA: gallic acid; GCG:
gallocatechin gallate | tr |
dc.language.iso | eng | tr |
dc.publisher | Journal of Biomolecular Structure and Dynamics | tr |
dc.relation.isversionof | https://doi.org/10.1080/07391102.2020.1840440 | tr |
dc.rights | info:eu-repo/semantics/openAccess | tr |
dc.subject | Carbonic anhydrase | tr |
dc.subject | acetylcholinesterase | tr |
dc.subject | a-glycosidase | tr |
dc.subject | antioxidant activity | tr |
dc.subject | Catechin 5-O-gallate | tr |
dc.title | Biological effects and molecular docking studies of Catechin 5-O-gallate: antioxidant, anticholinergics, antiepileptic and antidiabetic potentials | tr |
dc.type | article | tr |
dc.contributor.department | Sivas Meslek Yüksekokulu | tr |
dc.contributor.authorID | https://orcid.org/0000-0002-0420-2043 | tr |
dc.identifier.volume | 40 | tr |
dc.identifier.issue | 6 | tr |
dc.identifier.endpage | 2497 | tr |
dc.identifier.startpage | 2489 | tr |
dc.relation.publicationcategory | Uluslararası Editör Denetimli Dergide Makale | tr |