dc.contributor.author | Bayyurt, Burcu | |
dc.date.accessioned | 2023-06-22T07:21:11Z | |
dc.date.available | 2023-06-22T07:21:11Z | |
dc.date.issued | 2022 | tr |
dc.identifier.citation | Serdal Arslan1 | Mehmet Bakir2 | Burcu Bayyurt3 | Eylem I. Aydemir4 |
Kenan Kinaci5 | Aynur Engin2 Department of Medical Biology, Faculty of
Medicine, Mersin University, Mersin, Turkey
2
Department of Infectious Diseases and
Clinical Microbiology, Faculty of Medicine,
Sivas Cumhuriyet University, Sivas, Turkey
3
Department of Medical Biology, Faculty of
Medicine, Sivas Cumhuriyet University, Sivas,
Turkey
4
Department of Statistic, Faculty of Science,
Sivas Cumhuriyet University, Sivas, Turkey
5
SEM Laboratories, Istanbul, Turkey | tr |
dc.identifier.issn | 1096-9071 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/13917 | |
dc.description.abstract | Crimean Congo hemorrhagic fever (CCHF) is an acute viral infection that can cause
death. The detection of host transcriptome is important for understanding
differences in the pathogenesis of the disease. Long noncoding RNAs (lncRNAs)
regulate gene expression in different biological processes. They have also emerged
as key molecules for therapeutic targets. We investigated the lncRNA gene
expression profiles by utilizing the microarray for the first time in CCHF. LncRNAs
were determined by the comparisons between case‐control, fatal case‐control, and
fatal case‐nonfatal cases. Quantitative polymerase chain reaction was applied to
validate the microarray results of some lncRNAs. In our study, 39 lncRNAs
(5 downregulated and 34 upregulated) were found to be significantly regulated in
the cases when compared to the controls (p < 0.05; FC ≥ 2). One hundred ten
lncRNAs exhibited a statistically significant difference between fatal cases and
controls. FER1L4, ECRP, and LOC100133669 are important lncRNAs in both case
and fatal case groups compared with controls. These lncRNAs may be considered
important therapeutic targets for the CCHF in further studies. | tr |
dc.language.iso | eng | tr |
dc.publisher | Wiley | tr |
dc.relation.isversionof | 10.1002/jmv.27721 | tr |
dc.rights | info:eu-repo/semantics/openAccess | tr |
dc.subject | CCHF, gene expression, lncRNA, microarray, qPCR | tr |
dc.title | Long noncoding RNA expression analysis in Crimean Congo hemorrhagic fever patients | tr |
dc.type | article | tr |
dc.relation.journal | Journal of Medical Virology | tr |
dc.contributor.department | Tıp Fakültesi | tr |
dc.contributor.authorID | https://orcid.org/0000-0002-5618-457X | tr |
dc.identifier.issue | 94 | tr |
dc.identifier.endpage | 3262 | tr |
dc.identifier.startpage | 3257 | tr |
dc.relation.tubitak | info:eu-repo/grantAgreement/TUBITAK/SBAG/117S146 | |
dc.relation.publicationcategory | Uluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanı | tr |