Clinical value of serum BMP-4, BMP-2, GDF-15, MMP-9, GP39 levels in pregnant women with obesity and the related comorbidities diabetes mellitus and gestational hypertension
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Date
2023/2Author
YARŞILIKAL, GÜLEROĞLU FİLİZSELVİ, ESRA
TURAN, BAKIRCI ISIL
Bafalı, Olgu
Argun Atalmış, Hatice
YASTI DAYAN, MERVE
BALKAN, ÖZMEN ALİYE
YURTCU, NAZAN
Seker Atas, Busra
Özdemir Anayurt, Esma
ÇETİN, ALİ
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Yarsilikal Guleroglu F, Selvi E, Turan Bakirci I, Bafalı O, Argun Atalmis H, Yasti Dayan M, Balkan Ozmen A, Yurtcu N, Seker Atas B, Ozdemir Anayurt E, Cetin A. Clinical Value of Serum BMP-4, BMP-2, GDF-15, MMP-9, GP39 Levels in Pregnant Women with Obesity and the Related Comorbidities Diabetes Mellitus and Gestational Hypertension. Z Geburtshilfe Neonatol. 2023 Feb;227(1):42-50. doi: 10.1055/a-1937-1155. Epub 2022 Sep 28. PMID: 36170878.Abstract
Aims We evaluated the clinical value of selected serum biomarkers BMP-4, BMP-2, GDF-15, MMP-9, and GP39 in pregnant women with obesity and the comorbidities diabetes mellitus (DM) and gestational hypertension (GHT).
Methods This observational study had groups of controls, including healthy pregnant women; women with only obesity, including pregnant women with BMI≥30 kg/m2; women with gestational DM (GDM) with obesity, including pregnant women with GDM and obesity; women with pregestational DM (PGDM) with obesity, including pregnant women with PGDM and obesity; and women with GHT with obesity, including pregnant women with GHT and obesity. We measured serum levels of selected biomarkers by ELISA.
ResultsObesity increased serum levels of all the biomarkers; GDM developed in obese women caused a more pronounced increase in the serum levels of BMP-4 and BMP-2, and GHT developed in obese women caused a more pronounced increase in the serum levels of GDF-15. In the women with GDM-, PGDM-, and GHT-complicated obesity, serum levels of MMP-9 and GP39 did not change meaningfully.
Conclusions Obesity and its comorbidities DM and GHT lead to meaningful changes in the studied serum biomarkers. Since obesity has a causal effect on developing numerous conditions, reliable clinical biomarkers are needed to improve the early prediction and diagnosis of high-risk conditions during pregnancy.