| dc.description.abstract | In the present study, we synthesized carbon nanoparticles with a different method using chi tosan, a natural polymer. As a result, carbon nanomaterials were diffused directly through the
intestinal membrane, and carbon nanoparticles were obtained. Surface and chemical character izations of the obtained carbon nanoparticles were determined by different techniques such as
FTIR, DLS, SEM, EDX, and UV-visible. Moreover, the cytotoxic effects of the carbon nanoparti cles on Saos-2, MCF-7 cancer cells, and HUVEC non-cancerous cells were evaluated with the MTT
test. Although the size of these carbon nanoparticles is not as small as carbon nanodots, these
nanoparticles were very effective on cancer cells. Interestingly, our results showed that drug-free
carbon nanoparticles were remarkably cytotoxic on MCF-7 and Saos-2 cancer cells. In addition,
5FU loaded carbon nanoparticles (IC50: 12 μg/mL) were 3.5 times more effective than 5FU alone
(IC50: 43 μg/mL) on MCF-7 cell lines | tr |
