6 IN VITRO ANTIPROLIFERATIVE ACTIVITIES OF ROYAL JELLY COLLECTED FROM SIVAS IN HUMAN OVARIAN CANCER (SK-OV-3) CELL LINE

Abstract

Royal jelly has positive effects on human health. It is a bee product and functional food. Royal jelly is secreted from the glands of hypopharyngeal and mandibular secretion tissue of young worker bees. It is a viscous liquid with a sour taste and a white-yellowish color and has a special phenol smelling liquid. Royal jelly is health promoting food, and it is used in the production of cosmetic medical products. Most of the study in the literature, it has been shown that royal jelly has antibacterial, anti-inflammatory, vasodilator, hypotensive, antioxidant, antidiabetic, antihypercholesterolemic and antitumoral activities [1]. Within the aim of this study, royal jelly samples were obtained from various localities of Sivas province. Royal jelly samples were obtained from beekeepers in the 2020 harvest period. It was aimed to determine and compare the cytotoxic activity of royal jelly samples collected different area of Sivas province in SK-OV-3 (Human ovarian cancer) cell line using MTT test. MTT results were determined spectrophotometrically and IC50 values were calculated with Graphpad program. It was observed that some samples with a high concentration dosage and during 48 hour period showed good cytotoxic activity in this cell line. It is the first time to test the efficacy of royal jelly samples from Sivas region on the SKOV-3 cell line and this study will be a beginning in terms of the therapeutic use of bee royal jelly samples from Sivas province and the preparation of new effective supplements.