Agmatine, telomerase and trace minerals levels in patients with obstructive sleep apnea syndrome
Date
Şubat 2023Metadata
Show full item recordAbstract
Obstructive sleep apnea syndrome (OSAS) is a disease characterized by repetitive, partially or com plete upper airway obstructions resulting in hypoxia and bioelectrical wakefulness reactions along with sleep.
There is a limited and different information on the biochemical pathways that may determine harmful effects
in OSAS patients with different disease severity. Hence, we aimed to estimate the plasma levels of polyamine
agmatine, which has many effects on the central nervous system, telomerase and trace minerals in patients
with OSAS. The study included 90 volunteer patients diagnosed with OSAS and divided into three groups of 30
people each according to the apnea-hypopnea index (AHI) score: mild, moderate and severe. Nocturnal blood
oxygen saturation percentage (SpO2 ) and body mass index (BMI) were measured. Plasma agmatine level
was defined by ultra-high-pressure liquid chromatography (UHPLC), plasma trace elements (Cu, Co, Mg,
Mo, Zn, Se) level by inductively coupled plasma mass spectrometer (ICP-MS) and serum telomerase level by
enzyme-linked immunosorbent assay (EL ISA) method. It was found that SpO2
value decreased as the disease
progressed and showed a negative correlation with BMI, Co and Se plasma levels. The levels of agmatine and
telomerase were shown to lower in patients with severe OSAS group compared to other groups