dc.contributor.author | Akkaya, Birnur | |
dc.date.accessioned | 2024-02-27T06:27:50Z | |
dc.date.available | 2024-02-27T06:27:50Z | |
dc.date.issued | 2023 | tr |
dc.identifier.citation | - | tr |
dc.identifier.uri | https://www.sciencedirect.com/science/article/abs/pii/S014181302304391X?via%3Dihub | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/14339 | |
dc.description | ... | tr |
dc.description.abstract | In the present study, monolithic poly(N-isopropylacrylamide-acrylamide)-acrilic acid (poly(npam-aam)-aac) cryogels were made. Swelling tests, SEM, XRD, and ATR-FTIR analyses revealed distinct cryogel and lysozyme-loaded cryogel properties. The equilibrium swelling degree was 6.2 g H2O/g cryogel. The created poly(npam-aam)-aac with pores of 10–100 μm was obviously seen in SEM images. Lysozyme adsorption capacity on poly(npam-aam)-aac was found to be 260 mg/g at pH 7.4 and 40 °C. After that, we used lysozyme adsorbed cryogel for the removal of the model heavy metal ion (cadmium). A series of pH, duration, and ionic strengths were used to conduct Cd2+ adsorption experiments. The results showed that the new adsorbent had a considerable chemical affinity for Cd2+ ions in its ability to bind them under eye ocular conditions (pH 7.4, 32–36 °C, 0,15 M NaCl). The traditional Langmuir adsorption model was the most suitable, achieving maximum uptake of ∼185 mg/g. Chemical adsorption was found to be the rate-controlling step, and the process was also compatible with the pseudo-second-order model. For the treatment of ocular pathologies, the most effective enzyme, lysozyme, must show its function. That is why there is a need for using lysozyme, and lysozyme is selected as a lignad to adsorb heavy metal ions because of its high heavy metal binding affinity. This material could be used for the treatment of ocular pathologies in the future. | tr |
dc.description.sponsorship | ... | tr |
dc.language.iso | eng | tr |
dc.publisher | International Journal of Biological Macromolecules | tr |
dc.relation.isversionof | 10.1016/j.ijbiomac.2023.127494 | tr |
dc.rights | info:eu-repo/semantics/restrictedAccess | tr |
dc.subject | Cryogel, Eye diseases, Heavy metal, Immobilization, Lysozyme | tr |
dc.title | Preparation and characterization of lysozyme loaded cryogel for heavy metal removal | tr |
dc.type | article | tr |
dc.relation.journal | International Journal of Biological Macromolecules | tr |
dc.contributor.department | Fen Fakültesi | tr |
dc.contributor.authorID | 0000-0001-9139-1884 | tr |
dc.identifier.volume | 253 | tr |
dc.identifier.issue | 8 | tr |
dc.identifier.endpage | 494 | tr |
dc.identifier.startpage | 127 | tr |
dc.relation.publicationcategory | Uluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanı | tr |