Preventive effects of Capparis Spinose extract on experimental periodontitis in rats: a histopathological and biochemical study
Abstract
This study aimed to assess the effectiveness of Capparis Spinose (CS) in preventing the initiation and pro gression of experimental periodontitis and to evaluate the effect of its on systemic oxidative stress in rats by
experimental periodontitis model. Twenty-four male rats were equally divided into; Ligatured (L), non-liga tured (NL), and Ligatured with CS (11 days/day per 20 mg/kg) (LC) groups. Experimental periodontitis was
induced with the silk suture technic. Alveolar bone loss was examined, and total antioxidant capacity(TAOC),
total oxidant status(TOS), and oxidative stress index(OSI) were analyzed in rat serum. Although; alveolar bone
loss showed statistically significant lower values in the LC group compared to L (p < 0.05), not NL. In the
LC group, osteoclast and osteoblast numbers were statistically significant compared to L, but there were no
statistical differences between LC and NL. Serum TAOC levels were significantly lower in group L compared
to others and also LC group showed significant differences from NL. TOS and OSI levels were significantly
higher in group L than in other groups. Within the limitation of the present study, it can be said that the destruc tion via local inflammation that may occur after the experimental periodontitis can be prevented by using CS