Biological evaluation and in silico molecular docking studies of Abies cilicica (Antoine & Kotschy) Carrière) resin

Abstract

Abies cilicica (Antoine & Kotschy) Carri`ere) is an endemic species of industrial and medicinal importance. The resin obtained from this plant is effective for different diseases. The chemical content of the ethanol extract of Abies cilicica resin by GC-MS method, its antimicrobial activity on 12 different microorganisms by MIC value, antibiofilm activity on six microorganisms by Christensen method and biological activities on three different cancer cell lines by MTT method were investigated in this study. The findings showed that antimicrobial and antibiofilm activity was high in L. monocytogenes. The resin extract showed strong anticancer activity on all three DU-145, HeLa and SaOS-2 cells. The major component of the resin was abietic acid. A molecular docking simulation of the major compounds from resin extracts was conducted. In this study, in which the strong biological properties of A.cilicica resin were revealed, which suggests that the resin can increase the inhibition of cancer cell growth while strengthening the immune system against pathogenic microorganisms. Molecular docking analysis performed supported the experimental observations. Further extensive studies will support the possibility of using this resin as a therapeutic agent.