| dc.description.abstract | Diabetes Mellitus (DM) is a metabolic disorder that is very
common in our society, is caused by a combination of hereditary
and environmental factors, and results in an increase in blood
glucose levels. Diabetes mellitus develops as a result of increased
blood glucose level and impaired insulin secretion. Antioxidant
enzymes cannot be synthesized enough in patients with diabetes
mellitus and free radicals damage tissues. In this study, the effects of vitamin C and vitamin E on lipid
peroxidation and antioxidant enzyme activities in kidney tissue
of streptozotocin-induced diabetic rats were investigated. Male
wistar rats, were grouped into five each consisting 8 rats as (nondiabetic
control
(K),
diabetic
(D),
diabetic
Vitamin
E (E),
diabetic
Vitamin
C (C),
and
diabetic
Vitamin
E and
C (EC).
Diabetes
mellitus
was
induced
in rats
by
intraperitoneal
injection
of 55mg/
kg
STZ.
After
the injection,
i.p.
268mg/kg.
vitamin
E, 250 mg/
kg
vitamin
C by
gavage
were
administrated
for four weeks.
As
an
indicator
of lipid
peroxidation
malondialdehyde
(MDA)
levels,
antioxidant
enzymes
as superoxide
dismutase
(SOD),
catalase
(CAT)
and
and
glutothione
peroxides
(GSH-PX)
activities
were
measured
in kidney
tissue
homogenates.
In the study, MDA level of group D was significantly higher
than groups K, E, C and EC. Statistically significant difference
was not observed in CAT levels among the groups. SOD enzyme
levels in group D was higher compared to group K, and lower in
group EC compared to groups C, and D. GSH-Px enzyme levels
in group D and group C were significantly higher compared to
group K. Group D GSH-Px levels were significantly lower whwn
compared to group E, C and EC, GSH-Px levels of EC group was
lower compared to group C.
As a result, in this study it was demonstrated that vitamin C
and vitamin E have positive effect on lipid peoxidation and as a
result decreased the high levels of MDA, SOD, GSH-Px levels of
diabetic rat kidney tissues. | tr |
