| dc.description.abstract | Objective
The relationship between endometrial cancer and systemic inflammation has been evaluated in recent
years, particularly in terms of pre-treatment assessment, lymph node metastasis, and prognosis prediction.
However, a conclusive consensus on this topic has yet to be reached. This study is based on the retrospective
data from a tertiary center study conducted on patients who underwent surgery for endometrial cancer in our
clinic within the past 2 years. The aim of this research is to assess the potential effects of age, gravidity, parity,
hemoglobin (Hb), platelet (PLT), white blood cell count (WBC), lymphocyte count (LYM), monocyte count (MONO),
and calculated systemic inflammatory indexes (NLR, PLR, LMR, dNLR, SII, SIRI, PIV) on the diagnosis and
prognosis of endometrial cancer.
Methods
This study is based on the analysis of retrospective data from endometrial cancer patients treated at a single
center. Patient data including age, obstetric characteristics, and hematologic parameters were recorded. Systemic
inflammatory indexes were calculated using the following formulas: NLR (Neutrophil-to-lymphocyte ratio), PLR
(Platelet-to-lymphocyte ratio), LMR (Lymphocyte-to-monocyte ratio), dNLR (Derived NLR ratio - neutrophil count
divided by the result of leucocyte count minus neutrophil count), SII (Systemic inflammatory index - neutrophil x
platelet / lymphocyte), SIRI (Systemic inflammatory response index - neutrophil x monocyte / lymphocyte count),
and PIV (Pan-immune inflammation value - neutrophil x platelet x monocyte / lymphocyte count).
Results
Our study includes 21 patients who underwent surgery for endometrial cancer in our clinic within the past 2
years. We examined the relationships between age, obstetric characteristics, and hematologic parameters in
endometrial cancer patients. The results indicated that the mean age was 56.6 years, with an average gravidity of 3.
The average hemoglobin level was within the normal range at 12.7. The mean values for the systemic inflammatory
indexes were as follows: SII (694.6 ± 319.1) SIRI (1.4 ± 0.9) PIV (346.8 ± 137.2), NLR (2.9 ± 2.6), PLR (147.3 ± 51.7), LMR (4.1 ±
1.43), and dNLR (2.03 ± 1.6). In conclusion, the relationship between endometrial cancer and systemic inflammation is a
significant focal point for future cancer research and treatments. Current research findings in this area may
contribute to a better understanding of this relationship and improve the healthcare of patients. | tr |
