Synthesis and Caracterizations of New Thiosemicarbazone and Thiazole Derivatives From Polycyclic Chiral 1,5- Diketones
Tarih
08.11.2023Üst veri
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Thiosemicarbazone derivatives have a wide spectrum of biological
activity as well as various application areas such as
forming complexes with metals, using as intermediates in the
synthesis of heterocyclic bioactive compounds. Thiazole derivatives
can be easily synthesized from thiosemicarbazones and
are among the important compounds in demand in terms of
biological activity. In this study, 14 new thiosemicarbazone
derivatives were synthesized starting from polycyclic 1,5-
diketone derivatives with five stereocenters, and 14 thiazole
derivatives were synthesized from the reaction of the obtained
thiosemicarbazones with 2-bromoacetophenone and their
structure determinations were carried out using spectroscopic
methods (1H-NMR, 13C-NMR, 2D-NMR, FT-IR and Q-TOF LC/MS).
This synthesis route from polycyclic chiral 1,5-diketones may
contribute to the design of new drug-like molecules, which are
important in medicinal chemistry.