Synthesis of Bis-Nicotinonitrile Derivatives and Investigations of Antimicrobial and Antibiofilm Activities
Abstract
In this study aimed to the synthesis of novel bis-nicotinonitrile
derivatives starting from 1,3-bis-chalcones and investigate their
antimicrobial activity potentials. Bis-nicotinonitrile derivatives
were synthesized from 1,3-bis-chalcone derivatives reacted with
malononitrile in ethanol in the presence of potassium
carbonate. Characterization of the obtained compounds was
carried out by spectroscopic methods. In total, 12 new 1,3-
phenylene-bis-nicotinonitrile derivatives were synthesized. Finally,
the antimicrobial and antibiofilm activities of synthesized
1,3-phenylene-bis-nicotinonitrile derivatives were tested against
5 microorganisms. As a result, it was observed that the
synthesized new nicotinonitrile derivatives were quite active
especially in terms of antibiofilm activity.