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Captopril exhibits protective effects through anti-inflammatory and anti-apoptotic pathways against hydrogen peroxide-induced oxidative stress in C6 glioma cells
(Metabolic Brain Disease, 2022)
Recent studies have shown that angiotensin-converting enzyme (ACE) inhibitors have reduced oxidative damage in the central nervous system (CNS). Accumulating evidence have also demonstrated that captopril, an ACE inhibitor, ...
Role of lncRNAs in Remodeling of the Coronary Artery Plaques in Patients with Atherosclerosis
(2023)
Abstract
Introduction Cardiovascular diseases (CVDs) are the leading cause of death worldwide according to World Health Organi zation (WHO) data. Atherosclerosis is considered as a chronic infammatory disease that develops ...
Increased endoplasmic reticulum stress might be related to brain damage in hepatic ischemia-reperfusion injury
(2023)
Objectives: Our study aimed to investigate the role of
endoplasmic reticulum stress (ER) in brain damage following
hepatic ischemia-reperfusion (HIR) injury. Specifically, we
characterized the expression of markers of ...
The Effect of Cycle Threshold Value on Predicting Prognosis in CrimeanCongo Hemorrhagic Fever Disease
(22.12.2023)
Introduction: Crimean-Congo hemorrhagic fever (CCHF) disease is characterized by symptoms such as fever, headache, muscle aches, and bleeding. In severe cases, it can lead to death. Clinical and biochemical parameters, ...
Anticancer activity, hTERT expression and telomere length analysis in SH-SY5Y neuroblastoma cell lines applied to docetaxel
(Elsevier, 05.02.2023)
Neuroblastoma is the most common extracranial solid tumor of infancy in a broad range of clinical courses, ranging from spontaneous regression to fatal progression. Telomere maintenance plays an impor- tant role in genome ...
Experimental and theoretical insights about the effect of some newly designed azomethine group‐contained macroheterocycles on oxidative stress and DNA repair gene profiles in neuroblastoma cell lines
(Elsevier, 2023/8/5)
We report herein the synthesis of new azomethine group containing forty-, sixty-eight- and seventy- two-membered macroheterocyclic compounds and the investigation of their activity against the neurob- lastoma cell line. ...
Effect of azomethine group containing compounds on gene profiles in Wnt and MAPK signal patterns in lung cancer cell line: In silico and in vitro analyses
(Elsevier, 2023/3/5)
The main aims of anticancer drug development studies is to reduce the toxicity of the developed com pound and maximize the effectiveness, as well as the discovery of artificial and natural compounds. In
recent years, ...
In Silico and In Vitro Studies of Novel Azomethines on DNA Repair Genes in Gastric Cell Lines
(MDPI, 28.09.2023)
We herein report the determination of the cytotoxic activity and expression profiles of
some DNA repair genes of newly synthesized azomethines in the gastric cancer cell line (AGS). The
studied novel compounds were ...
Investigation of Early Growth Response Protein (EGR) Levels in Patients with Fibromyalgia Syndrome: A Cross-Sectional Study
(Bentham Science Publishers, 01.12.2023)
Background:
Fibromyalgia is a soft tissue rheumatism characterized by chronic and
widespread musculoskeletal pain at specific points in the body.
Objectives:
In this study, we aimed to investigate the relationship ...
Biological evaluation and in silico molecular docking studies of Abies cilicica (Antoine & Kotschy) Carrière) resin
(Elsevier, 2023/9/15)
Abies cilicica (Antoine & Kotschy) Carri`ere) is an endemic species of industrial and medicinal importance. The
resin obtained from this plant is effective for different diseases. The chemical content of the ethanol ...