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The 5-HT7 receptor antagonist SB-269970 alleviates seizure activity and downregulates hippocampal c-Fos expression in pentylenetetrazole-induced kindled rats
(NEUROLOGICAL RESEARCH, 2022)
Objectives: Recently, studies have demonstrated that serotonin type 7 receptors (5-HT7) have conflincting effects on neuronal excitability in different brain regions. However, the effect of 5-HT7 on seizures has not been ...
Captopril exhibits protective effects through anti-inflammatory and anti-apoptotic pathways against hydrogen peroxide-induced oxidative stress in C6 glioma cells
(Metabolic Brain Disease, 2022)
Recent studies have shown that angiotensin-converting enzyme (ACE) inhibitors have reduced oxidative damage in the central nervous system (CNS). Accumulating evidence have also demonstrated that captopril, an ACE inhibitor, ...
Role of lncRNAs in Remodeling of the Coronary Artery Plaques in Patients with Atherosclerosis
(2023)
Abstract
Introduction Cardiovascular diseases (CVDs) are the leading cause of death worldwide according to World Health Organi zation (WHO) data. Atherosclerosis is considered as a chronic infammatory disease that develops ...
Increased endoplasmic reticulum stress might be related to brain damage in hepatic ischemia-reperfusion injury
(2023)
Objectives: Our study aimed to investigate the role of
endoplasmic reticulum stress (ER) in brain damage following
hepatic ischemia-reperfusion (HIR) injury. Specifically, we
characterized the expression of markers of ...
Best Practices of Feature Selection in Multi-Omics Data
(IGI Global, 2023)
Today, there is an increase in data in many areas. With this increase, the number and variety of the variables
to be evaluated also increases. The increase in data and variables became a situation that needed
to be solved ...
The Effect of Cycle Threshold Value on Predicting Prognosis in CrimeanCongo Hemorrhagic Fever Disease
(22.12.2023)
Introduction: Crimean-Congo hemorrhagic fever (CCHF) disease is characterized by symptoms such as fever, headache, muscle aches, and bleeding. In severe cases, it can lead to death. Clinical and biochemical parameters, ...
Anticancer activity, hTERT expression and telomere length analysis in SH-SY5Y neuroblastoma cell lines applied to docetaxel
(Elsevier, 05.02.2023)
Neuroblastoma is the most common extracranial solid tumor of infancy in a broad range of clinical courses, ranging from spontaneous regression to fatal progression. Telomere maintenance plays an impor- tant role in genome ...
Collaborative Clinical Research on Metabolomics
(23.10.2023)
Metabolomics is the scientific study of chemical processes involving metabolites, substrates, intermediates, and namely all reagents and products of cell metabolism. Metabolomics and Clinical Approach will contribute to ...
Experimental and theoretical insights about the effect of some newly designed azomethine group‐contained macroheterocycles on oxidative stress and DNA repair gene profiles in neuroblastoma cell lines
(Elsevier, 2023/8/5)
We report herein the synthesis of new azomethine group containing forty-, sixty-eight- and seventy- two-membered macroheterocyclic compounds and the investigation of their activity against the neurob- lastoma cell line. ...
Joint Research on Perinatology
(12.07.2023)
Medical and surgical care have made considerable progress in the last two decades in the care of the mother, fetus, and neonate. Most of the improvement in outcomes has been related to advances in diagnostic and therapeutic ...