Browsing Cerrahi Tıp Bilimleri Bölümü Makale Koleksiyonu by Author "4b966be3-2562-4617-9ea5-5b574c396c5b"
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Aspirin attenuates morphine antinociceptive tolerance in rats with diabetic neuropathy by inhibiting apoptosis in the dorsal root ganglia
Ozdemir, Ercan; Avcı, Onur; Sahin Inan, Zeynep Deniz; Taskiran, Ahmet Sevki; Güneş, Handan; Gursoy, Sinan (2023)Morphine is a drug used in chronic pain such as diabetic neuropathy, but the development of tolerance to its antinoci ceptive efect is an important clinical problem. Aspirin is an analgesic and antiapoptotic drug used in ... -
Metformin prevents morphine‑induced apoptosis in rats with diabetic neuropathy: a possible mechanism for attenuating morphine tolerance
Avcı, Onur; Ozdemir, Ercan; Taskiran, Ahmet Sevki; Sahin Inan, Zeynep Deniz; Gursoy, Sinan (Springer, 2022)Morphine is a drug of choice for the treatment of severe and chronic pain, but tolerance to the antinociceptive efect limits its use. The development of tolerance to morphine has recently been associated with neuronal ...