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Parthenolide as a potential analgesic in the treatment of paclitaxel‑induced neuropathic pain: the rat modeling
(Haziran 20)
In this study, we determined the therapeutic efect of parthenolide (PTL), the active component of Tanacetum parthenium,
on neuropathic pain caused by paclitaxel (PTX), a chemotherapeutic drug frequently used in cancer ...
Evaluated periodontal tissues and oxidative stress in rats with neuropathic pain-like behavior
(Ekim 2023)
Background Oxidative stress has a critical effect on both persistent pain states and periodontal disease. Voltage-gated sodium
NaV1.7 (SCN9A), and transient receptor potential ankyrin 1 (TRPA1) are pain genes. The goal ...
FGF-18 alleviates memory impairments and neuropathological changes in a rat model of Alzheimer’s disease
(Temmuz 202)
Alzheimer’s disease (AD) is a multifactorial pathology marked by amyloid beta (Aβ) accumulation, tau hyper phosphorylation, and progressive cognitive decline. Previous studies show that fibroblast growth factor 18
(FGF18) ...
The Effects of Sunitinib in Healthy and Cisplatin-Induced Rats
(04.01.2023)
Sunitinib is a multitargeted kinase inhibitor that inhibits many receptor tyrosine kinases and has been used in the treatment of gastrointestinal stromal tumors, metastatic renal cell carcinoma, and pancreatic neuroendocrine ...
Protective effect of Allium scorodoprasum L. ethanolic extract in cyclophosphamide-induced hepatotoxicity model in rats
(20.02.2023)
Objectives Cyclophosphamide is a chemotherapeutic agent and immunosuppressant drug; however, it damages the liver. This study investigates the protective effect of ethanolic extract of Allium scorodoprasum (ASE) on ...
Effects of Lavender (Lavandula Angustifolia) Essential Oil on Fattening Performance, Meat Quality, Serum Antioxidant Enzymes, Gut Microbiota and Intestinal Histomorphology in Japanese Quails
(31.07.2023)
This study examined the effects of lavender essential oil on performance, meat quality, microbial load, fatty acid profile and gut microbiota in quails. In the study, 200 quails (Coturnix coturnix Japonica) were divided ...
The effects of sorafenib in healthy and cisplatin-treated rats
(07.10.2023)
Background. Sorafenib is a multikinase inhibitor currently used in the treatment of hepatocellular carcinoma, renal cell carcinoma and thyroid cancer.
Objectives. The literature on this agent is scarce. This study aimed ...
FGF-18 alleviates memory impairments and neuropathological changes in a rat model of Alzheimer's disease
(22.07.2023)
Alzheimer’s disease (AD) is a multifactorial pathology marked by amyloid beta (Aβ) accumulation, tau hyperphosphorylation, and progressive cognitive decline. Previous studies show that fibroblast growth factor 18 (FGF18) ...
Mechanism of anticancer effect of gambogic acid on gastric signet ring cell carcinoma
(16.08.2023)
Gambogic acid has demonstrated inhibitory effects on the growth of various cancer cell types, such as breast cancer, pancreatic cancer, prostate cancer, lung cancer, and osteosarcoma. This study aims to investigate the ...