Temel Tıp Bilimleri Bölümü Makale Koleksiyonu
Recent Submissions
-
Leukotriene metabolism and proiflammatory cytokines in Crimean Congo hemorrhagic fever
(01.01.2023)Crimean–Congo hemorrhagic fever (CCHF) is an emerging acute viral infection disease, yet its pathophysiology remains largely uncharacterized. Lipid mediators are molecules that play numerous roles in the physiologic and ... -
Effect of azomethine group containing compounds on gene profiles in Wnt and MAPK signal patterns in lung cancer cell line: In silico and in vitro analyses
(Elsevier, 2023/3/5)The main aims of anticancer drug development studies is to reduce the toxicity of the developed com pound and maximize the effectiveness, as well as the discovery of artificial and natural compounds. In recent years, ... -
Biological evaluation and in silico molecular docking studies of Abies cilicica (Antoine & Kotschy) Carrière) resin
(Elsevier, 2023/9/15)Abies cilicica (Antoine & Kotschy) Carri`ere) is an endemic species of industrial and medicinal importance. The resin obtained from this plant is effective for different diseases. The chemical content of the ethanol ... -
Experimental and theoretical insights about the effect of some newly designed azomethine group‐contained macroheterocycles on oxidative stress and DNA repair gene profiles in neuroblastoma cell lines
(Elsevier, 2023/8/5)We report herein the synthesis of new azomethine group containing forty-, sixty-eight- and seventy- two-membered macroheterocyclic compounds and the investigation of their activity against the neurob- lastoma cell line. ... -
Investigation of Early Growth Response Protein (EGR) Levels in Patients with Fibromyalgia Syndrome: A Cross-Sectional Study
(Bentham Science Publishers, 01.12.2023)Background: Fibromyalgia is a soft tissue rheumatism characterized by chronic and widespread musculoskeletal pain at specific points in the body. Objectives: In this study, we aimed to investigate the relationship ... -
In Silico and In Vitro Studies of Novel Azomethines on DNA Repair Genes in Gastric Cell Lines
(MDPI, 28.09.2023)We herein report the determination of the cytotoxic activity and expression profiles of some DNA repair genes of newly synthesized azomethines in the gastric cancer cell line (AGS). The studied novel compounds were ... -
Anticancer activity, hTERT expression and telomere length analysis in SH-SY5Y neuroblastoma cell lines applied to docetaxel
(Elsevier, 05.02.2023)Neuroblastoma is the most common extracranial solid tumor of infancy in a broad range of clinical courses, ranging from spontaneous regression to fatal progression. Telomere maintenance plays an impor- tant role in genome ... -
Antimicrobially effective protein-loaded metal chelated chitosan composite
(1 Ağustos )The immobilization of lysozyme onto a novel synthetic metal chelator composite based on chitosan/ PAA-PMA (chitosan/acrylamide-maleic acid) and its effect on antimicrobial activity were the aim of the current study. ... -
The Effect of Cycle Threshold Value on Predicting Prognosis in CrimeanCongo Hemorrhagic Fever Disease
(22.12.2023)Introduction: Crimean-Congo hemorrhagic fever (CCHF) disease is characterized by symptoms such as fever, headache, muscle aches, and bleeding. In severe cases, it can lead to death. Clinical and biochemical parameters, ... -
The experiences and thoughts of Turkish family physicians about COVID-19 pandemic: A qualitative study
(14.02.2023)Background: Efforts to contain the SARS-CoV-2 virus would fall short without strong primary health care. Objectives: In this study, we aimed to determine the experiences, views and suggestions of family physicians ... -
Medical Students' Views and Attitudes toward Vaccine Refusal during the COVID-19 Pandemic: A Multicenter Study
(20.04.2024)Background: The rapid development and production of COVID-19 vaccines have raised concerns about their safety and efficacy, which have contributed to vaccine hesitancy among some people. Objectives: This study aimed to ... -
The Turkish version of the problem areas in diabetes-parents of teens (P-PAID-T): Cross-cultural adaptation, reliability, and validity
(10.08.2023)Objective: To examine the Turkish validity and reliability of the Problem Areas in Diabetes- Parents of Teens (PPAID-T) scale and its psychometric properties for determining the parents’ diabetes-related distress. Methods: ... -
Novel Bioactive Glass/Graphene Oxide-Coated Surgical Sutures for Soft Tissue Regeneration
(2023)The combination of a commercially available PGLA (poly[glycolide-co-L-lactide]), 90:10% suture material with bio active bioglass nanopowders (BGNs) and graphene oxide (GO)- doped BGNs offers new opportunities for the ... -
Aspirin attenuates morphine antinociceptive tolerance in rats with diabetic neuropathy by inhibiting apoptosis in the dorsal root ganglia
(2023)Morphine is a drug used in chronic pain such as diabetic neuropathy, but the development of tolerance to its antinoci ceptive efect is an important clinical problem. Aspirin is an analgesic and antiapoptotic drug used in ... -
Preventive effects of Capparis Spinose extract on experimental periodontitis in rats: a histopathological and biochemical study
(2023)This study aimed to assess the effectiveness of Capparis Spinose (CS) in preventing the initiation and pro gression of experimental periodontitis and to evaluate the effect of its on systemic oxidative stress in rats by ... -
Anti-adhesive effect of naturally obtained dicalcium phosphate dihydrate nanoparticles in the rat uterine wound model
(2023)Objective: In this study, we aimed to compare the anti-adhesive effects of contractubex and dicalcium phosphate dihydrate (DCPD) particles in rats treated with the uterine horn adhesion model. Materials and methods: Newly ... -
The mechanism of anticancer effects of some pyrrolopyrimidine derivatives on HT-29 human colon cancer cells
(2023)In the present work, the mechanism of anticancer activity of some pyrrolopyrimidine derivatives was evaluated. Compounds 5 and 8 exhibiting significant antiproliferative activity against HT-29 cells with IC50 values of ... -
Investigating the Healing Effect of Hyperici Oleum and Triticum vulgare on Septal Perforation in Rats: A Preliminary Study
(2023)Objective: The aim of this study was to investigate histopathologically the possible beneficial effects of hyperici oleum and Triticum vulgare, having anti-inflammatory, antioxidant, and antiproliferative properties, on ... -
Toxoplasma gondii and multiple sclerosis: a population-based case-control seroprevalence study, Central Anatolia, Turkey
(2023)Background: Toxoplasma gondii, an obligate intracellular parasite, is prevalent in various mammalian species, as well as certain avian, reptilian, and cold-blooded organisms. While immunocompetent individuals generally remain ... -
Increased endoplasmic reticulum stress might be related to brain damage in hepatic ischemia-reperfusion injury
(2023)Objectives: Our study aimed to investigate the role of endoplasmic reticulum stress (ER) in brain damage following hepatic ischemia-reperfusion (HIR) injury. Specifically, we characterized the expression of markers of ...