Browsing Temel Tıp Bilimleri Bölümü Makale Koleksiyonu by Language "eng"
Now showing items 21-40 of 41
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In Silico and In Vitro Studies of Novel Azomethines on DNA Repair Genes in Gastric Cell Lines
(MDPI, 28.09.2023)We herein report the determination of the cytotoxic activity and expression profiles of some DNA repair genes of newly synthesized azomethines in the gastric cancer cell line (AGS). The studied novel compounds were ... -
Increased endoplasmic reticulum stress might be related to brain damage in hepatic ischemia-reperfusion injury
(2023)Objectives: Our study aimed to investigate the role of endoplasmic reticulum stress (ER) in brain damage following hepatic ischemia-reperfusion (HIR) injury. Specifically, we characterized the expression of markers of ... -
Investigation of Early Growth Response Protein (EGR) Levels in Patients with Fibromyalgia Syndrome: A Cross-Sectional Study
(Bentham Science Publishers, 01.12.2023)Background: Fibromyalgia is a soft tissue rheumatism characterized by chronic and widespread musculoskeletal pain at specific points in the body. Objectives: In this study, we aimed to investigate the relationship ... -
Investigation of the mechanisms involved in anticancer effect of glucosamine sulfate on SH-SY5Y cell line
(Bratislavske lekarske listy, 2022)Aim: Glucosamine derivatives have been found to have anticancer effects in many cancer cell lines in previous investigations. The effect of glucosamine sulfate on neuroblastoma, however, is uncertain. The potential cytotoxic ... -
Leukotriene metabolism and proiflammatory cytokines in Crimean Congo hemorrhagic fever
(01.01.2023)Crimean–Congo hemorrhagic fever (CCHF) is an emerging acute viral infection disease, yet its pathophysiology remains largely uncharacterized. Lipid mediators are molecules that play numerous roles in the physiologic and ... -
Long noncoding RNA expression analysis in Crimean Congo hemorrhagic fever patients
(Wiley, 2022)Crimean Congo hemorrhagic fever (CCHF) is an acute viral infection that can cause death. The detection of host transcriptome is important for understanding differences in the pathogenesis of the disease. Long noncoding ... -
Melatonin levels and microRNA (miRNA) relative expression profile in the follicular ambient microenvironment in patients undergoing in vitro fertilization process
(2021)Abstract Purpose Intrafollicular fluid (IFF) melatonin plays a decisive role in maintaining granulosa cells’ DNA integrity and protects them against apoptosis. It reduces oxidative stress and improves the oocyte quality ... -
Mitochondrial Homeostasis and Mast Cells in Experimental Hepatic Ischemia-Reperfusion Injury of Rats.
(2022)Background: Ischemia-reperfusion injury is a histopathological event and is an important cause of morbidity and mortality after hepatobiliary surgery. We aimed to investigate the protective effect of uridine on hepatic ... -
Potassium Ion Channel Protein (KCNH) Levels in Patients with Fibromyalgia Syndrome
(CMB Association Publiher, 2021)Although there is not yet full clarity of the pathogenesis of fibromyalgia syndrome (FM), central sensitization is considered to be responsible. The purpose of this study was to measure the plasma levels of potassium ion ... -
A radiological study about the incidence of ureteral anomalies. Number of the ureters on 4160 cases
(1996)Purpose: The aim of this study were determined the incidence of ureteral anomalies. Methods: A total of 4160 intravenous pyelographies were examined for the incidence of anomalies of number of the ureter. Results: Unilateral ... -
Role of lncRNAs in Remodeling of the Coronary Artery Plaques in Patients with Atherosclerosis
(2023)Abstract Introduction Cardiovascular diseases (CVDs) are the leading cause of death worldwide according to World Health Organi zation (WHO) data. Atherosclerosis is considered as a chronic infammatory disease that develops ... -
Synergistic efficacy of meropenem, ciprofloxacin and colistin antibiotics against planktonic and biofilm forms of Myroides odoratimimus bacterial isolates
(Eylül 2022)Purpose: In this study, it was aimed to investigate the combined synergistic efficacy of colistin (CT), meropenem (MEM), and ciprofloxacin (CIP) antibiotics on planktonic and biofilm forms in Myroidesodoratimimus strains ... -
Synthesis, characterization, antimicrobial and antibiofilm activity, and molecular docking analysis of NHC precursors and their Ag-NHC complexes†
(The Royal Society of Chemistry, 2 November)Microorganisms attach to surfaces and interfaces and form biofilms which create a sheltered area for host cell response. Therefore, biofilms provide troubles in fields such as medicine, food, and pharmaceuticals. Inhibition ... -
Synthesis, computational analyses, antibacterial and antibiofilm properties of nicotinamide derivatives
(Ağustos 20)Newly designed nicotinamide derivatives were synthesized and characterized using spectral techniques (IR, 1H-NMR, 13C-NMR, and MS). Moreover, these compounds are investigated computationally. B3LYP/6–31 + G(d,p) level is ... -
The 5-HT7 receptor antagonist SB-269970 alleviates seizure activity and downregulates hippocampal c-Fos expression in pentylenetetrazole-induced kindled rats
(NEUROLOGICAL RESEARCH, 2022)Objectives: Recently, studies have demonstrated that serotonin type 7 receptors (5-HT7) have conflincting effects on neuronal excitability in different brain regions. However, the effect of 5-HT7 on seizures has not been ... -
The Effect of Cycle Threshold Value on Predicting Prognosis in CrimeanCongo Hemorrhagic Fever Disease
(22.12.2023)Introduction: Crimean-Congo hemorrhagic fever (CCHF) disease is characterized by symptoms such as fever, headache, muscle aches, and bleeding. In severe cases, it can lead to death. Clinical and biochemical parameters, ... -
The relationship between serum prolidase activity and histone H3 protein levels and fibromyalgia
(VERDUCI PUBLISHERVIA GREGORIO VII, ROME 186-00165, ITALY, 2022)OBJECTIVE: Fibromyalgia (FM) is a clinical syndrome characterized by prominent physical and psychological impairment and widespread pain on both sides of the body, above and below the waist, and along the axial skeleton. ... -
The use of laboratory parameters and computed tomography score to determine intensive care unit requirement in COVID-19
(2021)Objectives It is vital to determine the intensive care unit (ICU) requirement at an early stage to reduce the mortality rate in COVID-19 patients. The aim of the study was to find reliable predictive markers to determine ... -
Thiamine alleviates cognitive impairment and epileptogenesis by relieving brain inflammation in PTZ-induced kindling rat model
(NEUROLOGICAL RESEARCH, 2022)khg -
Understanding the pathophysiological changes via untargeted metabolomics in COVID‐19 patients
(Wiley, 2021 Nisan)Coronavirus disease 2019 (COVID-19) is an infectious respiratory disease caused by a new strain of the coronavirus. There is limited data on the pathogenesis and the cellular responses of COVID-19. In this study, we aimed ...