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In Silico and In Vitro Studies of Novel Azomethines on DNA Repair Genes in Gastric Cell Lines
(MDPI, 28.09.2023)
We herein report the determination of the cytotoxic activity and expression profiles of
some DNA repair genes of newly synthesized azomethines in the gastric cancer cell line (AGS). The
studied novel compounds were ...
Anticancer activity, hTERT expression and telomere length analysis in SH-SY5Y neuroblastoma cell lines applied to docetaxel
(Elsevier, 05.02.2023)
Neuroblastoma is the most common extracranial solid tumor of infancy in a broad range of clinical courses, ranging from spontaneous regression to fatal progression. Telomere maintenance plays an impor- tant role in genome ...
In vitro cytotoxic effects, in silico studies, some metabolic enzymes inhibition, and vibrational spectral analysis of novel β-amino alcohol compounds
(Elsevier, 05.02.2023)
In this study, an efficient single-step method for the preparation of β-amino alcohols ( 1 –3 ) in aqueous media was applied. The aim was to investigate the cytotoxic activity of Compounds 1, 2 and 3 in neu- roblastoma ...
Experimental and theoretical insights about the effect of some newly designed azomethine group-contained macroheterocycles on oxidative stress and DNA repair gene profiles in neuroblastoma cell lines
(Elsevier, 05.09.2023)
We report herein the synthesis of new azomethine group containing forty-, sixty-eight- and seventy- two-membered macroheterocyclic compounds and the investigation of their activity against the neurob- lastoma cell line. ...
Effect of azomethine group containing compounds on gene profiles in Wnt and MAPK signal patterns in lung cancer cell line: In silico and in vitro analyses
(Elsevier, 05.03.2023)
The main aims of anticancer drug development studies is to reduce the toxicity of the developed compound and maximize the effectiveness, as well as the discovery of artificial and natural compounds. In recent years, ...
The investigation of host genetic variants of toll-like receptor 7 and 8 in COVID-19
(2023)
Toll-like receptors (TLRs) recognize infectious agents and play an important role in the innate immune system. Studies have suggested that TLR single nucleotide polymorphisms (SNPs) are associated with poor antiviral ...
Investigation of Early Growth Response Protein (EGR) Levels in Patients with Fibromyalgia Syndrome: A Cross-Sectional Study
(MDPI, 01.12.2023)
Background: Fibromyalgia is a soft tissue rheumatism characterized by chronic and widespread musculoskeletal pain at specific points in the body.
Objectives: In this study, we aimed to investigate the relationship between ...
Synthesis and Caracterizations of New Thiosemicarbazone and Thiazole Derivatives From Polycyclic Chiral 1,5- Diketones
(08.11.2023)
Thiosemicarbazone derivatives have a wide spectrum of biological
activity as well as various application areas such as
forming complexes with metals, using as intermediates in the
synthesis of heterocyclic bioactive ...
Synthesis of Bis-Nicotinonitrile Derivatives and Investigations of Antimicrobial and Antibiofilm Activities
(02.10.2023)
In this study aimed to the synthesis of novel bis-nicotinonitrile
derivatives starting from 1,3-bis-chalcones and investigate their
antimicrobial activity potentials. Bis-nicotinonitrile derivatives
were synthesized ...
Serum visfatin levels are positively correlated with dietary carbohydrate and polyunsaturated fatty acid intakes in type 2 diabetes mellitus patients
(Elsevier, 2023)
Aims
To investigate the relationship between dietary intake and biochemical parameters and anthropometric measurements and serum visfatin concentrations.
Study design
A case-control study.
Methods
The study was ...