Browsing Temel Eczacılık Bilimleri Bölümü by Title
Now showing items 42-61 of 114
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Development of quantum dot-phthalocyanine integrated G-quadruplex /double-stranded DNA biosensor
(Elsevier, 2022)In the present study, the phthalocyanine (Pc) integrated mercaptopropionic acid capped quantum dot (mpa@QD) biosensor has been developed for the quantitative determination of G-quadruplex and doublestranded DNA. The ... -
Development of quantum dot-phthalocyanine integrated G-quadruplex/double-stranded DNA biosensor
(1 October )n the present study, the phthalocyanine (Pc) integrated mercaptopropionic acid capped quantum dot (mpa@QD) biosensor has been developed for the quantitative determination of G-quadruplex and double-stranded DNA. The working ... -
Emerging Trends in Pharmacotoxicological and Forensic Sample Treatment Procedures
(MDPI, 22 Februar)One of the most discussed topics concerns the sample preparation before the analysis and, therefore, all the operations necessary to eliminate the interferents, clean up the specimens, and extract the analytes of interest, ... -
Evaluation of the effects of newly synthesized metallophthalocyanines on breast cancer cell lines with photodynamic therapy
(2022)In this study, the new phthalonitrile derivative 3-(4-(3-oxobutyl)phenoxy)phthalonitrile (1) and its non peripheral metallophthalocyanine derivatives [zinc (2), copper (3), cobalt (4), manganese (5), gallium (6), and ... -
Evaluation of the effects of newly synthesized metallophthalocyanines on breast cancer cell lines with photodynamic therapy
(Royal Society of Chemistry, 21.09.2022)In this study, the new phthalonitrile derivative 3-(4-(3-oxobutyl)phenoxy)phthalonitrile (1) and its nonperipheral metallophthalocyanine derivatives [zinc (2), copper (3), cobalt (4), manganese (5), gallium (6), and ... -
EXTRACTION AND DETERMINATION OF Cd, Co, Se, V AND Ag LEVELS IN COW’S MUSCLE, LIVER, KIDNEY, LUNG, SPLEEN AND BRAIN SAMPLES
(2022/4/1)A deep eutectic solvent (DES) consisting of oxalic acid and choline chloride was prepared and used to extract Cd, Co, Se, V, and Ag from meats. The metal levels were determined in muscle, liver, kidney, lung, spleen, ... -
Fabric-Phase Sorptive Membrane Array As a Noninvasive In Vivo Sampling Device For Human Exposure To Different Compounds
(ACs, 20.01.2021)This study introduces an innovative device for the noninvasive sampling and chromatographic analysis of different compounds present in exhaled breath aerosol (EBA). The new sampling device, especially in light of the ... -
Güncel Uygulanan Kanser Tedavi Yöntemleri
(Bilgin Kültür Sanat Yayınları, 25.12.2022)Modern tıp her ne kadar ilerlemiş olsa da kanser için hastalık görülmeden önce ortaya çıkarılması ve erken safhada önlenmesi hala çok önemlidir. Kansere karşı koruyucu olarak; en büyük nedenlerinden biri olan sigara ve ... -
Imidazole‐hydrazone derivatives: Synthesis, characterization, X‐ray structures and evaluation of anticancer and carbonic anhydrase I–II inhibition properties
(19.06.2023)The nine new imidazole-hydrazone derivatives of Schiff base were synthesized from the condensation reactions of 1-methyl1H-imidazole-2-carbaldehyde with various substitutedhydrazide derivatives. Structures of the final ... -
Imidazole‐hydrazone derivatives: Synthesis, characterization, X‐ray structures and evaluation of anticancer and carbonic anhydrase I–II inhibition properties
(Chemistry Europe, 2023/7/20)The nine new imidazole-hydrazone derivatives of Schiff base were synthesized from the condensation reactions of 1-methyl1H-imidazole-2-carbaldehyde with various substitutedhydrazide derivatives. Structures of the final ... -
IMMUNOTHERAPY IN CANCER TREATMENT
(31.06.2023)Cancer, which causes the death of approximately 10 million people every year, is a type of disease that begins to spread to other parts of the body by uncontrolled proliferation of cells in the tissues and organs of our ... -
Interaction of water soluble cationic gallium (III) phthalocyanines with different G-quadruplex DNAs
(Elsevier, 1 November)Small molecule-G-quadruplex DNA interaction has been gained considerable interest due to existence of G-quadruplex structures in telomeres and promotor regions of proto-oncogenes. In the present study, the interaction of ... -
Investigation of Binding behaviour of a water-soluble gallium (III) phthalocyanine with double-stranded and G-quadruplex DNA via experimental and computational methods
(2021/9/15)DNA is an important target for the development of chemotherapeutic drug design due to increased and uncontrolled cell proliferation of cancer cells. In the present study, the affinity of water-soluble gallium(III) ... -
Investigation of Interaction of Bismarck Brown Y-Palladium Complex with AS1411 G-quadruplex Aptamer
(29.12.2022)Increased metabolic activity and metastasis are the main and most known characteristics of cancer cells. Increased activity of the cells results in an increase in the transcription, translation, and replication rate of ... -
Investigation of possible associations between tryptophan/kynurenine status and FOXP3 expression in colorectal cancer
(2022)Tryptophan metabolism in the tumor microenvironment exerts immunosuppressive effects by affecting the anti-tumor functions of immune cells. The immunosuppressive roles of tryptophan and tryptophan metabolites and their ... -
INVESTIGATION OF SALVIA CADMICA’S ANTIOXIDANT PROPERTIES AND CYTOTOXIC PROPERTIES IN BREAST CANCER CELL LINE AND ITS APOPTOTIC INDUCTION
(30.05.2023)Salvia cadmica is an endemic species known to have antioxidant, antimicrobial and aromatic properties and the existence of Salvia species is known to date back to 753 BC. This species, whose medicinal properties were ... -
Investigation of the Antimicrobial Agent Potential of 1,5-diketon Derivatives
(2021)In this study 1,5-diketones were synthesized by adding of cyclohexzanone to five differtent calcone derivatives (1a-e) via di-1,4-Michael addition reaction. As a result the compounds with the best activity were 3a, 3b and ... -
INVESTIGATION OF THE ANTIPROLIFERATIVE EFFECT OF SALVIA CADMICA ON COLON CANCER
(07.05.2023)Salvia cadmica is an endemic species known to have antioxidant, antimicrobial and aromatic properties and the existence of Salvia species is known to date back to 753 BC. This species, whose medicinal properties were ... -
Investigation of the Relationship between the Chemical Structures and the Cytotoxicity of Some Maleic Anhydride-Containing Copolymers as Polymeric Drug Carriers
(23.11.2023)Polymer-based substances have been an important biomaterial in the advancement of drug delivery systems as they enabled the controlled release of therapeutic agents in fixed doses with high bioavailability, lower toxicity, ... -
Isatin/thiosemicarbohydrazone hybrids: Facile synthesis, and their evaluation as anti-proliferatıve agents and metabolıc enzyme inhibitors
(AJOL, 2023/7/3)We are reporting a novel series of thiosemicarbazone derivatives derived from isatin (1-6), structural determination, and investigation of the inhibitory properties against proliferative, carbonic anhydrase, and cholinesterase ...