Browsing Temel Eczacılık Bilimleri Bölümü by Title
Now showing items 82-101 of 114
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Pulicaria Gaertn. Cinsinin Bazı Türleri Üzerinde Yapılan Güncel Araştırmalar
(Gece Kitaplığı, Eylül 2021)Pulicaria cinsi Asteraceae familyası içerisinde yer almaktadır ve ilk kez 1791 yılında Gaertner tarafından tanımlanmıştır. Asya, Avrupa, Afrika ve Arap yarımadasında dağılım göstermektedir (Anderberg, 2009). Yeryüzünde ... -
Pyrazolyl‐Benzoxazinone Derivatives as Dual Hsp Inhibitors in Human Breast Cancer
(2022)Heat Shock Proteins (Hsps) play major role on the onset of several cancers. Metabolic rates of cancer cells are higher compared to that of untransformed cells. This accelerated rate force functional substrate proteins to ... -
Removal of sulfadiazine from aqueous solution by magnetic biochar prepared with pomegranate peel
(Taylor&Francis, 17/05/2022)Magnetic biochar (Fe3O4-BCPP) was prepared by using iron oxide nanoparticles, and biochar which is obtained from pomegranate peel. The Fe3O4-BCPP were characterized by Brunauer-Emmett-Teller analysis, X-ray diffraction ... -
Selective cytotoxicity of paclitaxel bonded silver nanoparticle on different cancer cells
(2021)Paclitaxel (PTX) is one of the most effective drugs in the treatment of cancer. However, its usability is limited due to low solubility and side effects. In this study, we investigated anticancer effects of PTX bonded ... -
Sensitive determination of Anastrozole and Letrozole in urine samples by novel magnetic nanoparticles containing tetraethylenepentamine (TEPA) prior to analysis by high-performance liquid chromatography-diode array detection
(Springer, 20.02.2022)Magnetic solid-phase extraction coupled to high-performance liquid chromatography (HPLC)-diode array detection method has been developed for the sensitive analysis of Anastrozole (ANA) and Letrozole (LET) in human urine ... -
Sensitive determination of Fluoxetine and Citalopram antidepressants in urine and wastewater samples by liquid chromatography coupled with photodiode array detector
(02.05.2021)A new analyte separation and preconcentration method for the trace determination of antidepressant drugs, Fluoxetine (FLU) and Citalopram (CIT) in urine and wastewaters, was developed based on HPLC-DAD analysis after ... -
Sensitive determination of Fluoxetine and Citalopram antidepressants in urine and wastewater samples by liquid chromatography coupled with photodiode array detector
(Elsevier, 26.04.2021)A new analyte separation and preconcentration method for the trace determination of antidepressant drugs, Fluoxetine (FLU) and Citalopram (CIT) in urine and wastewaters, was developed based on HPLC- DAD analysis after ... -
Synthesis and biological evaluation of thiosemicarbazone derivatives
(Springer US, 2022/07/21)In this study, firstly, 22 thiosemicarbazone derivatives (3a-y) were synthesized. Then, ADME parameters, pharmacokinetic properties, drug-like structures, and suitability for medicinal chemistry of these molecules were ... -
Synthesis and Molecular Docking of New N-Acyl Hydrazones- Benzimidazole as hCA I and II Inhibitors
(20.01.2023)Background: The carbonic anhydrases (CAs) which are found in most living organisms is a member of the zinc-containing metalloenzyme family. The abnormal levels and activities are frequently associated with various diseases ... -
Synthesis of (4R)-2-(3-hydroxyphenyl)thiazolidine 4-carboxylic acid substituted phthalocyanines: Anticancer activity on different cancer cell lines and molecular docking studies
(2021)In this study, firstly, (4R)-2-(3-hydroxyphenyl)thiazolidine-4-carboxylic acid (1) and (4R)-2-(3-(3,4-dicyanophenoxy)phenyl)thiazolidine-4-carboxylic acid (2) were prepared. Then, the novel type metallophthalocyanines ... -
Synthesis of Benzimidazole-1,2,4-triazole Derivatives as Potential Antifungal Agents Targeting 14α-Demethylase
(19.01.2023)Invasive fungal infections (IFIs) are increasing as major infectious diseases around the world, and the limited efficacy of existing medications has resulted in substantial morbidity and death in patients due to the lack ... -
Synthesis of Bis-Nicotinonitrile Derivatives and Investigations of Antimicrobial and Antibiofilm Activities
(Ekim 2023)In this study aimed to the synthesis of novel bis-nicotinonitrile derivatives starting from 1,3-bis-chalcones and investigate their antimicrobial activity potentials. Bis-nicotinonitrile derivatives were synthesized from ... -
Synthesis of New 1-Aryl-2-(3,5-dimethylpyrazol-1-yl)ethanone Oxime Ether Derivatives and Investigation of Their Cytotoxic Effects
(2021): In this study, 12 new 1-aryl-2-(3,5-dimethylpyrazol-1-yl)ethanone oxime ether derivatives were designed and synthesized to investigate their cytotoxic effects. The in vitro cytotoxic activities of the compounds were ... -
Synthesis, and docking studies of novel tetrazole S-alkyl derivatives as antimicrobial agents
(Taylor & Francis, 01.09.2022)A series of novel tetrazole-S-alkyl-piperazine derivatives were synthesized and evaluated for their antifungal activity against C. albicans (ATCC 24433), C. krusei (ATCC 6258) and C. parapsilosis (ATCC 22019) and ... -
Synthesis, and docking studies of novel tetrazole-S-alkyl derivatives as antimicrobial agents
(07.01.2023)A series of novel tetrazole-S-alkyl-piperazine derivatives were synthesized and evaluated for their antifungal activity against C. albicans (ATCC 24433), C. krusei (ATCC 6258) and C. parapsilosis (ATCC 22019) and ... -
Synthesis, biological evaluation and in silico studies of novel thiadiazole-hydrazone derivatives for carbonic anhydrase inhibitory and anticancer activities
(04.08.2023)ABSTRACT Thiadiazole and hydrazone derivatives (5a–5i) were synthesized and their chemical structures were verified and described by 1 H NMR, 13 C NMR, and HRMS spectra. Three cancer cell lines (MCF-7, MDA, and ... -
Synthesis, Biological Evaluation and In Silico Studies of Some 2‐Substituted Benzoxazole Derivatives as Potential Anticancer Agents to Breast Cancer
(2022)In an attempt to develop potent and selective anticancer agents, some 5- or 6- and N-substituted benzoxazol-2-carbox amide derivatives were designed, synthesized, and evaluated for their cyclooxygenase inhibitory, antioxidant, ... -
Synthesis, carbonic anhydrase inhibitory activity, anticancer activity and molecular docking studies of new imidazolyl hydrazone derivatives
(Elsevier, 2022/12/05)A new series of imidazolyl hydrazone derivatives IA (1-12) were prepared from a condensation reaction between indoline-2,3-dione (isatin) and 2-benzylidenehydrazinecarboximidamide derivatives. The structure of compounds ... -
Synthesis, characterization, and application of polyacrylamide/carmine polymer nanomaterial as an effective solid-phase material for ultrasonic-assisted solid-phase microextraction of aluminum and chromium in vegetable samples
(2022)Here, a new and inexpensive polymer nanomaterial consisting of polyacrylamide and carmine (PAM-CR) was synthesized to provide selective extraction of aluminum and chromium from vegetable samples prior to their determination ... -
Synthesis, characterization, antimicrobial and antibiofilm activity, and molecular docking analysis of NHC precursors and their Ag-NHC complexes†
(The Royal Society, 2021)Microorganisms attach to surfaces and interfaces and form biofilms which create a sheltered area for host cell response. Therefore, biofilms provide troubles in fields such as medicine, food, and pharmaceuticals. Inhibition ...