Search
Now showing items 91-100 of 114
New benzimidazole‐oxadiazole derivatives: Synthesis, α‐glucosidase, α‐amylase activity, and molecular modeling studies as potential antidiabetic agents
(23.01.2023)
Benzimidazole‐1,3,4‐oxadiazole derivatives (5a–z) were synthesized and characterized
with different spectroscopic techniques such as
1
HNMR,
13
CNMR,andHRMS.The
synthesized analogs were examined against α‐glucosidase ...
Synthesis of Benzimidazole-1,2,4-triazole Derivatives as Potential Antifungal Agents Targeting 14α-Demethylase
(19.01.2023)
Invasive fungal infections (IFIs) are increasing as major infectious diseases
around the world, and the limited efficacy of existing medications has resulted in
substantial morbidity and death in patients due to the lack ...
New imidazole derivatives as aromatase inhibitor: Design, synthesis, biological activity, molecular docking, and computational ADME-Tox studies
(06.01.2023)
In this study, a series of imidazole derivatives was designed, synthesized, and evaluated for in vitro bi-
ological activity on the human breast cancer cell line MCF7 by MTT assay. To determine the selectivity
of the ...
INVESTIGATION OF THE ANTIPROLIFERATIVE EFFECT OF SALVIA CADMICA ON COLON CANCER
(07.05.2023)
Salvia cadmica is an endemic species known to have antioxidant, antimicrobial and aromatic
properties and the existence of Salvia species is known to date back to 753 BC. This species,
whose medicinal properties were ...
Biologically active phthalocyanine metal complexes: Preparation, evaluation of α‐glycosidase and anticholinesterase enzyme inhibition activities, and molecular docking studies
(Wiley-VCH GmbH, Weinheim, 2021/6)
In this study, preparation, as well as investigation of α‐glycosidase and cholinesterase
(ChE) enzyme inhibition activities of furan‐2‐ylmethoxy‐substituted compounds
1–7, are reported. Peripherally, tetra‐substituted ...
Imidazole‐hydrazone derivatives: Synthesis, characterization, X‐ray structures and evaluation of anticancer and carbonic anhydrase I–II inhibition properties
(Chemistry Europe, 2023/7/20)
The nine new imidazole-hydrazone derivatives of Schiff base
were synthesized from the condensation reactions of 1-methyl1H-imidazole-2-carbaldehyde with various substitutedhydrazide derivatives. Structures of the final ...
Design, synthesis and biological evaluation of novel ketone derivatives containing benzimidazole and 1,3,4-triazole as CA inhibitors
(03.10.2023)
In this study, we synthesized a series of new benzimidazole-triazole (6a-6k) derivatives and characterized them by 1 H NMR, 13C NMR, and HRMS. These compounds were evaluated for their inhibitory activity against hCA-I and ...
Anti-adhesive effect of naturally obtained dicalcium phosphate dihydrate nanoparticles in the rat uterine wound model
(2023)
Objective: In this study, we aimed to compare the anti-adhesive effects of contractubex and dicalcium phosphate dihydrate
(DCPD) particles in rats treated with the uterine horn adhesion model. Materials and methods: Newly ...
Isatin/thiosemicarbohydrazone hybrids: Facile synthesis, and their evaluation as anti-proliferatıve agents and metabolıc enzyme inhibitors
(AJOL, 2023/7/3)
We are reporting a novel series of thiosemicarbazone derivatives derived from isatin (1-6), structural determination, and investigation of the inhibitory properties against proliferative, carbonic anhydrase, and cholinesterase ...
IMMUNOTHERAPY IN CANCER TREATMENT
(31.06.2023)
Cancer, which causes the death of approximately 10 million people
every year, is a type of disease that begins to spread to other parts of the body
by uncontrolled proliferation of cells in the tissues and organs of our ...