Browsing Temel Eczacılık Bilimleri Bölümü Makale Koleksiyonu by Issue Date
Now showing items 61-80 of 104
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1, 2, 3-Triazole substituted phthalocyanine metal complexes as potential inhibitors for anticholinesterase and antidiabetic enzymes with molecular docking studies
(Taylor & Francis, 2022/01/26)In recent years, acetylcholinesterase (AChE) and α-glycosidase (α-gly) inhibition have emerged as a promising and important approach for pharmacological intervention in many diseases such as glaucoma, epilepsy, obesity, ... -
Phthalocyanine complexes with (4-isopropylbenzyl) oxy substituents: preparation and evaluation of anti-carbonic anhydrase, anticholinesterase enzymes and molecular docking studies
(Taylor & Francis, 2022/01/26)n this study, the preparation, aggregation behavior and investigation of carbonic anhydrase and cholinesterase enzyme inhibition features of non-peripherally (4-isopropylbenzyl)oxy-substituted phthalocyanines (4–6) are ... -
Biological effects and molecular docking studies of Catechin 5-O-gallate: Antioxidant, anticholinergics, antiepileptic and antidiabetic potentials
(Taylor & Francis, 2022/04/13)Gallocatechin gallate is a form of catechin and an ester of gallocatechin and gallic acid. This is an epimer of the gallate epigallocatechin. In this study, the effect of this molecule, containing a biologically active ... -
Synthesis and biological evaluation of thiosemicarbazone derivatives
(Springer US, 2022/07/21)In this study, firstly, 22 thiosemicarbazone derivatives (3a-y) were synthesized. Then, ADME parameters, pharmacokinetic properties, drug-like structures, and suitability for medicinal chemistry of these molecules were ... -
Determination of biological studies and molecular docking calculations of isatin-thiosemicarbazone hybrid compounds
(Elsevier, 2022/09/15)Design, synthesis, structural elucidation, and investigation of cytotoxic and antimicrobial activity, butyrylcholinesterase (BChE), and acetylcholinesterase (AChE) enzyme inhibition effects of isatinthiosemicarbazone ... -
Arylated quinoline and tetrahydroquinolines: Synthesis, characterization and their metabolic enzyme inhibitory and antimicrobial activities
(Chemstry Europa, 2022/10/07)The aims of this study are to synthesize and characterize some new phenyl quinoline derivatives and to determine the activities of them and the recently prepared substituted phenyl quinolines against Acetylcholinesterase ... -
Synthesis, carbonic anhydrase inhibitory activity, anticancer activity and molecular docking studies of new imidazolyl hydrazone derivatives
(Elsevier, 2022/12/05)A new series of imidazolyl hydrazone derivatives IA (1-12) were prepared from a condensation reaction between indoline-2,3-dione (isatin) and 2-benzylidenehydrazinecarboximidamide derivatives. The structure of compounds ... -
EXTRACTION AND DETERMINATION OF Cd, Co, Se, V AND Ag LEVELS IN COW’S MUSCLE, LIVER, KIDNEY, LUNG, SPLEEN AND BRAIN SAMPLES
(2022/4/1)A deep eutectic solvent (DES) consisting of oxalic acid and choline chloride was prepared and used to extract Cd, Co, Se, V, and Ag from meats. The metal levels were determined in muscle, liver, kidney, lung, spleen, ... -
Use of newly synthetized magnetic Fe3O4 nanoparticles modified with hexadecyl trimethyl ammonium bromide for the sensitive analysis of antidepressant drugs, duloxetine and vilazodone in wastewater and urine samples
(2023)A new enrichment and determination method involving HPLC-DAD analysis following magnetic solidphase extraction (MSPE) was developed to detect trace amounts of two antidepressant drugs, namely, duloxetine (DUL) and ... -
Propolis nanoparticles synthesis and characterization with cytotoxic and apoptotic effects on breast cancer cells
(2023)The aim of this work was to investigate the antiproliferative and pro-apoptotic effects of propolis on human breast cancer cells using a simple and inexpensive nanoformulation. Various meth ods were used to characterize ... -
Anti-adhesive effect of naturally obtained dicalcium phosphate dihydrate nanoparticles in the rat uterine wound model
(2023)Objective: In this study, we aimed to compare the anti-adhesive effects of contractubex and dicalcium phosphate dihydrate (DCPD) particles in rats treated with the uterine horn adhesion model. Materials and methods: Newly ... -
Novel Bioactive Glass/Graphene Oxide-Coated Surgical Sutures for Soft Tissue Regeneration
(2023)The combination of a commercially available PGLA (poly[glycolide-co-L-lactide]), 90:10% suture material with bio active bioglass nanopowders (BGNs) and graphene oxide (GO)- doped BGNs offers new opportunities for the ... -
Cytotoxic, Antioxidant, Antibiofilm, and Antimicrobial Activities of Mushroom Species from Turkey
(2023)Mushrooms, which have been collected to meet the nutritional needs of the world for many years, have gained medical importance thanks to the bioactive compounds they produce. Thanks to studies carried out to determine ... -
New Fluoro- and Trifluoromethyl-Substituted Trimethoxychalcones as Anticancer Agents: Synthesis, Bioevaluation, and Computational Studies
(2023)We designed and synthesized a novel series of trimethoxy chalcones with CF3 or F substituents at various positions of ring B, characterized using IR, NMR spectral data, and elemental analyses, based on the fact that ... -
Plant‑inspired adhesive and injectable natural hydrogels: in vitro and in vivo studies
(2023)The development of alternative thera peutic treatments based on the use of medicinal and aromatic plants, such as Juniper communis L., has aroused interest in the medical feld to fnd new alter natives to conventional ... -
Use of Fe3O4@ MPTMS-Dithizone Magnetic Nanoparticles as Solid Phase Sorbent for Sensitive Analysis of Sibutramine Molecules in Herbal Slimming Products.
(2023)Background: A new enrichment and sensitive determination method, which includes HPLCDAD analysis after Magnetic Solid Phase Extraction (MSPE), has been developed for trace analysis of Sibutramine molecules in herbal ... -
Vitamin D increases the efcacy of cisplatin on bladder cancer cell lines
(2023)Background 1,25(OH)2D3(Calcitriol), which is a broad regulatory molecule, plays a role in changing the efcacy of chemo therapeutic drugs. Cisplatin is one of a current standard chemotherapy regimen for bladder cancer. ... -
Composition characterization and biological activity study of Achillea vermicularis extract and extract‐loaded nanoparticles
(JUMB, 2023/1/9)Antiproliferative activity of Achillea vermicularis extracts was calculated on glial (C6) and keratinocyte (HaCaT) cell lines using XTT assay. It was observed that all extracts of A. vermicularis at the determined concentration ... -
Piperazin incorporated Schiff Base derivatives: Assessment of in vitro biological activities, metabolic enzyme inhibition properties, and molecular docking calculations
(WİLEY, 2023/11)The cytotoxic activities of the compounds were determined by the 3‐(4, 5‐dimethylthiazolyl‐2)‐2,5‐diphenyltetrazolium bromide (MTT) method in human breast cancer (MCF‐7), human cervical cancer (HeLa), and mouse fibroblast ... -
Molecular hybrids integrated with imidazole and hydrazone structural motifs: Design, synthesis, biological evaluation, and molecular docking studies
(Elsevier, 2023/12/1)In the present work, a series of compounds containing imidazole and hydrazone structural frameworks were synthesized and characterized using various spectral techniques, including 1H NMR, 13C NMR, FTIR, and HRMS. Synthesized ...