Browsing Temel Eczacılık Bilimleri Bölümü Makale Koleksiyonu by Title
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Imidazole‐hydrazone derivatives: Synthesis, characterization, X‐ray structures and evaluation of anticancer and carbonic anhydrase I–II inhibition properties
(19.06.2023)The nine new imidazole-hydrazone derivatives of Schiff base were synthesized from the condensation reactions of 1-methyl1H-imidazole-2-carbaldehyde with various substitutedhydrazide derivatives. Structures of the final ... -
Imidazole‐hydrazone derivatives: Synthesis, characterization, X‐ray structures and evaluation of anticancer and carbonic anhydrase I–II inhibition properties
(Chemistry Europe, 2023/7/20)The nine new imidazole-hydrazone derivatives of Schiff base were synthesized from the condensation reactions of 1-methyl1H-imidazole-2-carbaldehyde with various substitutedhydrazide derivatives. Structures of the final ... -
Interaction of water soluble cationic gallium (III) phthalocyanines with different G-quadruplex DNAs
(Elsevier, 1 November)Small molecule-G-quadruplex DNA interaction has been gained considerable interest due to existence of G-quadruplex structures in telomeres and promotor regions of proto-oncogenes. In the present study, the interaction of ... -
Investigation of Binding behaviour of a water-soluble gallium (III) phthalocyanine with double-stranded and G-quadruplex DNA via experimental and computational methods
(2021/9/15)DNA is an important target for the development of chemotherapeutic drug design due to increased and uncontrolled cell proliferation of cancer cells. In the present study, the affinity of water-soluble gallium(III) ... -
Investigation of Interaction of Bismarck Brown Y-Palladium Complex with AS1411 G-quadruplex Aptamer
(29.12.2022)Increased metabolic activity and metastasis are the main and most known characteristics of cancer cells. Increased activity of the cells results in an increase in the transcription, translation, and replication rate of ... -
Investigation of possible associations between tryptophan/kynurenine status and FOXP3 expression in colorectal cancer
(2022)Tryptophan metabolism in the tumor microenvironment exerts immunosuppressive effects by affecting the anti-tumor functions of immune cells. The immunosuppressive roles of tryptophan and tryptophan metabolites and their ... -
Investigation of the Antimicrobial Agent Potential of 1,5-diketon Derivatives
(2021)In this study 1,5-diketones were synthesized by adding of cyclohexzanone to five differtent calcone derivatives (1a-e) via di-1,4-Michael addition reaction. As a result the compounds with the best activity were 3a, 3b and ... -
Isatin/thiosemicarbohydrazone hybrids: Facile synthesis, and their evaluation as anti-proliferatıve agents and metabolıc enzyme inhibitors
(AJOL, 2023/7/3)We are reporting a novel series of thiosemicarbazone derivatives derived from isatin (1-6), structural determination, and investigation of the inhibitory properties against proliferative, carbonic anhydrase, and cholinesterase ... -
Magnetic solid-phase extraction coupled to high-performance liquid chromatography (HPLC)-diode array detection method has been developed for the sensitive analysis of Anastrozole (ANA) and Letrozole (LET) in human urine samples. Characterization studies of the newly synthesized material (Fe3O4@TEPA) were carried out by Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction, Raman spectroscopy, and scanning electron microscope techniques. The method has provided linearity for both the analytes (r2 > 0.9900) in the range of 4.00–160.00 ng mL−1. The limit of detections for ANA and LET was found to be 1.14 and 1.26 ng mL−1, respectively. The limit of quantification for ANA and LET was obtained 3.78 and 3.86 ng mL−1, respectively. The new method was simple, convenient, fast, and suitable for the direct analysis of ANA and LET in urine samples. Finally, the developed method was applied to the spiked human urine samples to test accuracy and repeatability. Recovery values for each of the molecules were calculated in the range of 93.4–108.0% (n = 3) at two concentration levels, while % RSDs were lower than 6.2%. Graphical abstract
(Elsevier, 15.04.2022)A new Polyacrylamide (PAA)-Vermiculite (V) composite was synthesized and characterized with the help of FTIR, SEM, and PZC analyses. The effects of ion concentration, pH and ionic strength parameters to adsorption process ... -
Michael/Michael Addition Cascade of 2-Benzylidene-1- indanones with Chalcones: Synthesis and Biological Evaluations of Novel Polycyclic Compounds
(WİLLEY ONLİNE LİBRARY, 2021)A series of novel racemic 2-aryloyl-1,3-diaryl-2,3,3a,8a-tetrahydrocyclopenta[ a]inden-8(1H)-one derivatives were synthesized from KOtBu mediated Michael/Michael addition reaction of 2- benzylidene-1-indanones with ... -
Michael/Michael Addition Cascade of 2-Benzylidene-1- indanones with Chalcones: Synthesis and Biological Evaluations of Novel Polycyclic Compounds
(2021)A series of novel racemic 2-aryloyl-1,3-diaryl-2,3,3a,8a-tetrahy drocyclopenta[a]inden-8(1H)-one derivatives were synthesized from KOtBu mediated Michael/Michael addition reaction of 2- benzylidene-1-indanones with ... -
Molecular hybrids integrated with imidazole and hydrazone structural motifs: Design, synthesis, biological evaluation, and molecular docking studies
(Elsevier, 2023/12/1)In the present work, a series of compounds containing imidazole and hydrazone structural frameworks were synthesized and characterized using various spectral techniques, including 1H NMR, 13C NMR, FTIR, and HRMS. Synthesized ... -
Nanocomposite smart hydrogel based on sepiolite nanochannels/N-isopropyl acrylamide/itaconic acid/acrylamide for invertase immobilization
(2021)Novel nanocomposite smart hydrogel (NSH) and smart hydrogel (SH) are prepared to be used as a support for invertase. Spectrophotometric and thermal analysis methods were used for the characterization. Lower critical ... -
New benzimidazole‐oxadiazole derivatives: Synthesis, α‐glucosidase, α‐amylase activity, and molecular modeling studies as potential antidiabetic agents
(23.01.2023)Benzimidazole‐1,3,4‐oxadiazole derivatives (5a–z) were synthesized and characterized with different spectroscopic techniques such as 1 HNMR, 13 CNMR,andHRMS.The synthesized analogs were examined against α‐glucosidase ... -
New Fluoro- and Trifluoromethyl-Substituted Trimethoxychalcones as Anticancer Agents: Synthesis, Bioevaluation, and Computational Studies
(2023)We designed and synthesized a novel series of trimethoxy chalcones with CF3 or F substituents at various positions of ring B, characterized using IR, NMR spectral data, and elemental analyses, based on the fact that ... -
New imidazole derivatives as aromatase inhibitor: Design, synthesis, biological activity, molecular docking, and computational ADME-Tox studies
(06.01.2023)In this study, a series of imidazole derivatives was designed, synthesized, and evaluated for in vitro bi- ological activity on the human breast cancer cell line MCF7 by MTT assay. To determine the selectivity of the ... -
Novel Applications of Microextraction Techniques Focused on Biological and Forensic Analyses
(MDPI, 15.02.2022)In recent years, major attention has been focused on microextraction procedures that allow high recovery of target analytes, regardless of the complexity of the sample matrices. The most used techniques included liquid-liquid ... -
Novel Bioactive Glass/Graphene Oxide-Coated Surgical Sutures for Soft Tissue Regeneration
(2023)The combination of a commercially available PGLA (poly[glycolide-co-L-lactide]), 90:10% suture material with bio active bioglass nanopowders (BGNs) and graphene oxide (GO)- doped BGNs offers new opportunities for the ... -
One-pot modification of oleate-capped UCNPs with AS1411 G-quadruplex DNA in a fully aqueous medium
(5 June 202)In the present work, modification of oleate-capped upconverting nanoparticles (OA@UCNPs) with AS1411 G-quadruplex DNA by a one-pot aqueous strategy was presented. The G-quadruplex structure of AS1411 and structural alterations ... -
Phthalocyanine complexes with (4-isopropylbenzyl) oxy substituents: preparation and evaluation of anti-carbonic anhydrase, anticholinesterase enzymes and molecular docking studies
(Taylor & Francis, 2022/01/26)n this study, the preparation, aggregation behavior and investigation of carbonic anhydrase and cholinesterase enzyme inhibition features of non-peripherally (4-isopropylbenzyl)oxy-substituted phthalocyanines (4–6) are ...