Browsing Temel Eczacılık Bilimleri Bölümü Makale Koleksiyonu by Author "Ümit M Koçyiğit"
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Composition characterization and biological activity study of Achillea vermicularis extract and extract‐loaded nanoparticles
Murat Doğan; Ümit M Koçyiğit; Feyza Nur Çetin; Beyza Nur Yılmaz; Turgut Taşkın (JUMB, 2023/1/9)Antiproliferative activity of Achillea vermicularis extracts was calculated on glial (C6) and keratinocyte (HaCaT) cell lines using XTT assay. It was observed that all extracts of A. vermicularis at the determined concentration ... -
Isatin/thiosemicarbohydrazone hybrids: Facile synthesis, and their evaluation as anti-proliferatıve agents and metabolıc enzyme inhibitors
Hasan Yakan; Mohammed Azam; Sevgi Kansız; Halit Muğlu; Mustafa Ergül; Parham Taslimi; Ümit M Koçyiğit; Muhammet Karaman; Saud I Al-Resayes; Kim Min (AJOL, 2023/7/3)We are reporting a novel series of thiosemicarbazone derivatives derived from isatin (1-6), structural determination, and investigation of the inhibitory properties against proliferative, carbonic anhydrase, and cholinesterase ... -
Molecular hybrids integrated with imidazole and hydrazone structural motifs: Design, synthesis, biological evaluation, and molecular docking studies
Michael Tapera; Hüseyin Kekeçmuhammed; Emin Sarıpınar; Murat Doğan; Burak Tüzün; Ümit M Koçyiğit; Feyza Nur Çetin (Elsevier, 2023/12/1)In the present work, a series of compounds containing imidazole and hydrazone structural frameworks were synthesized and characterized using various spectral techniques, including 1H NMR, 13C NMR, FTIR, and HRMS. Synthesized ... -
Piperazin incorporated Schiff Base derivatives: Assessment of in vitro biological activities, metabolic enzyme inhibition properties, and molecular docking calculations
Arif Mermer; Burak Tüzün; Sevgi Durna Daştan; Ümit M Koçyiğit; Feyza Nur Çetin; Özge Çevik (WİLEY, 2023/11)The cytotoxic activities of the compounds were determined by the 3‐(4, 5‐dimethylthiazolyl‐2)‐2,5‐diphenyltetrazolium bromide (MTT) method in human breast cancer (MCF‐7), human cervical cancer (HeLa), and mouse fibroblast ...