Browsing Temel Eczacılık Bilimleri Bölümü Makale Koleksiyonu by Author "0000-0002-8058-0994"
Now showing items 1-7 of 7
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ALLYL FUNCTIONALIZED BENZIMIDAZOLIUM-DERIVED AG(I)-N-HETEROCYCLIC CARBENE COMPLEXES: ANTI-BIOFILM AND ANTIMICROBIAL PROPERTIES
TUTAR, UĞUR; Çelik, Cem; Şahin, Neslihan (April, 202)Microorganisms in the biofilm structure cause severe health problems and economic losses. Therefore, it is very important to design and screen anti-biofilm molecules that can solve the related problems. This paper is aimed ... -
Antimicrobial activity, inhibition of biofilm formation, and molecular docking study of novel Ag-NHC complexes
TUTAR, UĞUR; ŞAHİN, NESLİHAN; ÜSTÜN, ELVAN; ÇELİK, CEM; GÜRBÜZ, NEVİN; ÖZDEMİR, İSMAİL (ELSEVİER, 2021)In this study, we reported the synthesis of a new series of Silver(I)-N-heterocyclic carbene complexes which were obtained from the corresponding new N-heterocyclic carbene (NHC) precursors. All new compounds were ... -
Antimicrobial and antibiofilm activities and bovine serum albumin binding properties of benzimidazolium derivative NHC salts and their Ag(I)-NHC complexes
Çelik, Cem; Üstün, Elvan; Şahin, Neslihan; Tutar, Uğur (December 2)Benzimidazole type N-heterocyclic carbene molecules and their metal complexes have well-known biological activity. Elemental silver and silver complexes also have antibacterial and antifungal activity. In this study, ... -
Antimicrobial, anti-biofilm and cytotoxic properties of methallyl functionalized benzimidazolium-derived Ag(I)-Nheterocyclic carbene complexes
Çelik, Cem; Tutar, Uğur; Şahin, Neslihan; Öztürk, Ayşegül (April 2022)Purpose: To investigate the antimicrobial, antibiofilm, and cytotoxicity properties of methallyl substituted benzimidazolium-based, silver-bound N-heterocyclic carbene (Ag(I)-NHC) complexes, with respect to their potential ... -
Investigation of the Antimicrobial Agent Potential of 1,5-diketon Derivatives
TUTAR, UĞUR; GEZEGEN, HAYREDDİN; KORKMAZ, GÜRSEL (2021)In this study 1,5-diketones were synthesized by adding of cyclohexzanone to five differtent calcone derivatives (1a-e) via di-1,4-Michael addition reaction. As a result the compounds with the best activity were 3a, 3b and ... -
Michael/Michael Addition Cascade of 2-Benzylidene-1- indanones with Chalcones: Synthesis and Biological Evaluations of Novel Polycyclic Compounds
TUTAR, UĞUR; GEZEGEN, HAYREDDİN; CEYLAN, HEPOKUR; TÜZÜN, GAMZE; ATİOĞLU, ZELİHA; AKKURT, MEHMET (WİLLEY ONLİNE LİBRARY, 2021)A series of novel racemic 2-aryloyl-1,3-diaryl-2,3,3a,8a-tetrahydrocyclopenta[ a]inden-8(1H)-one derivatives were synthesized from KOtBu mediated Michael/Michael addition reaction of 2- benzylidene-1-indanones with ... -
Synthesis, characterization, antimicrobial and antibiofilm activity, and molecular docking analysis of NHC precursors and their Ag-NHC complexes†
TUTAR, UĞUR; ÜSTÜN, ELVAN; ŞAHİN, NESLİHAN; ÇELİK, CEM; ÖZDEMİR, NAMIK; GÜRBÜZ, NEVİN; ÖZDEMİR, İSMAİL (The Royal Society, 2021)Microorganisms attach to surfaces and interfaces and form biofilms which create a sheltered area for host cell response. Therefore, biofilms provide troubles in fields such as medicine, food, and pharmaceuticals. Inhibition ...