Browsing Temel Eczacılık Bilimleri Bölümü Makale Koleksiyonu by Category "Uluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanı"
Now showing items 1-20 of 37
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Antimicrobial activity, inhibition of biofilm formation, and molecular docking study of novel Ag-NHC complexes
(ELSEVİER, 2021)In this study, we reported the synthesis of a new series of Silver(I)-N-heterocyclic carbene complexes which were obtained from the corresponding new N-heterocyclic carbene (NHC) precursors. All new compounds were ... -
Antimicrobial, anti-biofilm and cytotoxic properties of methallyl functionalized benzimidazolium-derived Ag(I)-Nheterocyclic carbene complexes
(April 2022)Purpose: To investigate the antimicrobial, antibiofilm, and cytotoxicity properties of methallyl substituted benzimidazolium-based, silver-bound N-heterocyclic carbene (Ag(I)-NHC) complexes, with respect to their potential ... -
Application of cloud point extraction for residues of chloramphenicol and amoxicillin in milk samples by HPLC–DAD
(Springer, 2022)A pre-concentration and sensitive determination method for residues of Chloramphenicol (CLP) and Amoxicillin (AMX) in milk samples were developed based on cloud point extraction (CPE) and HPLC–DAD analysis. CLP and AMX ... -
Application of magnetic solid‑phase extraction for sensitive determination of anticancer drugs in urine by means of diamino benzidine tetrachlorohydrate modified magnetic nanoparticles
(Şubat, 202)Background The analysis of drug active molecules and residues in the treatment of cancer is important for the sustainability of human life and therapeutic effects. For this purpose, a new magnetic sorbent was developed ... -
Arylated quinoline and tetrahydroquinolines: Synthesis, characterization and their metabolic enzyme inhibitory and antimicrobial activities
(Chemstry Europa, 2022/10/07)The aims of this study are to synthesize and characterize some new phenyl quinoline derivatives and to determine the activities of them and the recently prepared substituted phenyl quinolines against Acetylcholinesterase ... -
Benzimidazole-hydrazone derivatives: Synthesis, in vitro anticancer, antimicrobial, antioxidant activities, in silico DFT and ADMET studies
(Elsevier, 14.08.2022)Based on the biologically active heterocycle compounds, a series of new benzimidazole-hydrazone deriva- tives ( 3a-3j ) were synthesized, starting from 4-(6-chloro-1 H -benzimidazol-2-yl) benzohydrazide. The syn- thesized ... -
Biologically active phthalocyanine metal complexes: Preparation, evaluation of α‐glycosidase and anticholinesterase enzyme inhibition activities, and molecular docking studies
(Wiley-VCH GmbH, Weinheim, 2021/6)In this study, preparation, as well as investigation of α‐glycosidase and cholinesterase (ChE) enzyme inhibition activities of furan‐2‐ylmethoxy‐substituted compounds 1–7, are reported. Peripherally, tetra‐substituted ... -
BSA/DNA binding behavior and the photophysicochemical properties of novel water soluble zinc (II) phthalocyanines directly substituted with piperazine groups
(2021/6)In the current research, two novel zinc(II) phthalocyanines (ZnPcs) (1 and 2) directly connecting with 4-(4-methylpiperazin-1-yl)phenyl groups have been synthesized through the Suzuki–Miyaura coupling reaction. These ZnPcs ... -
Composition characterization and biological activity study of Achillea vermicularis extract and extract‐loaded nanoparticles
(JUMB, 2023/1/9)Antiproliferative activity of Achillea vermicularis extracts was calculated on glial (C6) and keratinocyte (HaCaT) cell lines using XTT assay. It was observed that all extracts of A. vermicularis at the determined concentration ... -
Decoration, Characterization and Antimicrobial Activity Evaluation of Novel Nano-Based 1,2-Phenylenediamine Functionalized Maleic Anhydride-Allylphenyl Ether Conjugate
(Chemistry Europe, 02 October)1,2-Phenylenediamine (o-PDA) is a well-known fluorescent dye that enables the decoration of next generation chemotherapeutics. A novel o-PDA-functionalized maleic anhydride-allyl phenyl ether (poly(MA-alt-APE)/o-PDA ... -
Deep Eutectic Solvent-based Extraction of As, Mn, Pb, Cr, and Ni from Spleen, Kidney, and Brain Samples
(14 Septemb)Deep eutectic solvent extraction for As, Mn, Pb, Cr, and Ni from spleen, kidney, and brain samples was investigated. The experimental parameters such as type and amount of deep eutectic solvent and sample/deep eutectic ... -
Design, synthesis and biological evaluation of novel ketone derivatives containing benzimidazole and 1,3,4-triazole as CA inhibitors
(03.10.2023)In this study, we synthesized a series of new benzimidazole-triazole (6a-6k) derivatives and characterized them by 1 H NMR, 13C NMR, and HRMS. These compounds were evaluated for their inhibitory activity against hCA-I and ... -
Design, synthesis and molecular docking studies of novel benzimidazole-1,3,4-oxadiazole hybrids for their carbonic anhydrase inhibitory and antioxidant effects
(Medicinal Chemistry Research, 08.08.2022)In this study, eleven new compounds with a series of benzimidazole-1,3,4-oxadiazole derivatives structures were synthesized and evaluated for their human (h) carbonic anhydrase inhibitory activities against two isoforms ... -
Design, synthesis, and molecular docking studies of benzimidazole‐1,3,4‐triazole hybrids as carbonic anhydrase I and II inhibitors
(30.08.2023)In this study, with an aim to develop novel heterocyclic hybrids as potent enzyme inhibitors, we synthesized a series of 10 novel 2- (4- (4- ethyl- 5- (2- (substitutedph enyl)- 2- oxo- ethylthio)- 4H- 1,2,4- triazol- 3- ... -
Determination of phenolic compounds in human saliva after oral administration of red wine by high performance liquid chromatography
(Elsevier, 05.02.2022)Search ScienceDirect Outline Highlights Abstract Keywords 1. Introduction 2. Materials and methods 3. Results and discussion 4. Conclusions Declaration of Competing Interest Acknowledgments Appendix A. Supplementary ... -
Development of quantum dot-phthalocyanine integrated G-quadruplex/double-stranded DNA biosensor
(1 October )n the present study, the phthalocyanine (Pc) integrated mercaptopropionic acid capped quantum dot (mpa@QD) biosensor has been developed for the quantitative determination of G-quadruplex and double-stranded DNA. The working ... -
Evaluation of the effects of newly synthesized metallophthalocyanines on breast cancer cell lines with photodynamic therapy
(Royal Society of Chemistry, 21.09.2022)In this study, the new phthalonitrile derivative 3-(4-(3-oxobutyl)phenoxy)phthalonitrile (1) and its nonperipheral metallophthalocyanine derivatives [zinc (2), copper (3), cobalt (4), manganese (5), gallium (6), and ... -
Imidazole‐hydrazone derivatives: Synthesis, characterization, X‐ray structures and evaluation of anticancer and carbonic anhydrase I–II inhibition properties
(19.06.2023)The nine new imidazole-hydrazone derivatives of Schiff base were synthesized from the condensation reactions of 1-methyl1H-imidazole-2-carbaldehyde with various substitutedhydrazide derivatives. Structures of the final ... -
Imidazole‐hydrazone derivatives: Synthesis, characterization, X‐ray structures and evaluation of anticancer and carbonic anhydrase I–II inhibition properties
(Chemistry Europe, 2023/7/20)The nine new imidazole-hydrazone derivatives of Schiff base were synthesized from the condensation reactions of 1-methyl1H-imidazole-2-carbaldehyde with various substitutedhydrazide derivatives. Structures of the final ... -
Interaction of water soluble cationic gallium (III) phthalocyanines with different G-quadruplex DNAs
(Elsevier, 1 November)Small molecule-G-quadruplex DNA interaction has been gained considerable interest due to existence of G-quadruplex structures in telomeres and promotor regions of proto-oncogenes. In the present study, the interaction of ...