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Synthesis of Bis-Nicotinonitrile Derivatives and Investigations of Antimicrobial and Antibiofilm Activities
(Ekim 2023)
In this study aimed to the synthesis of novel bis-nicotinonitrile derivatives starting from 1,3-bis-chalcones and investigate their antimicrobial activity potentials. Bis-nicotinonitrile derivatives were synthesized from ...
Imidazole‐hydrazone derivatives: Synthesis, characterization, X‐ray structures and evaluation of anticancer and carbonic anhydrase I–II inhibition properties
(19.06.2023)
The nine new imidazole-hydrazone derivatives of Schiff base
were synthesized from the condensation reactions of 1-methyl1H-imidazole-2-carbaldehyde
with various substitutedhydrazide
derivatives. Structures of the final ...
Design, synthesis, and molecular docking studies of benzimidazole‐1,3,4‐triazole hybrids as carbonic anhydrase I and II inhibitors
(30.08.2023)
In this study, with an aim to develop novel heterocyclic hybrids as potent enzyme
inhibitors, we synthesized a series of 10 novel 2- (4- (4- ethyl- 5- (2- (substitutedph
enyl)- 2- oxo- ethylthio)- 4H- 1,2,4- triazol- 3- ...
Synthesis and Molecular Docking of New N-Acyl Hydrazones- Benzimidazole as hCA I and II Inhibitors
(20.01.2023)
Background: The carbonic anhydrases (CAs) which are found in most living organisms is a member of the zinc-containing metalloenzyme family. The abnormal levels and activities are frequently associated with various diseases ...
Synthesis, and docking studies of novel tetrazole-S-alkyl derivatives as antimicrobial agents
(07.01.2023)
A series of novel tetrazole-S-alkyl-piperazine derivatives were synthesized and evaluated for their
antifungal activity against C. albicans (ATCC 24433), C. krusei (ATCC 6258) and C. parapsilosis (ATCC
22019) and ...
Synthesis, biological evaluation and in silico studies of novel thiadiazole-hydrazone derivatives for carbonic anhydrase inhibitory and anticancer activities
(04.08.2023)
ABSTRACT
Thiadiazole and hydrazone derivatives (5a–5i) were synthesized
and their chemical structures were verified and described by
1
H NMR,
13
C NMR, and HRMS spectra. Three cancer cell lines
(MCF-7, MDA, and ...
Molecular hybrids integrated with imidazole and hydrazone structural motifs: Design, synthesis, biological evaluation, and molecular docking studies
(Elsevier, 2023/12/1)
In the present work, a series of compounds containing imidazole and hydrazone structural frameworks were synthesized and characterized using various spectral techniques, including 1H NMR, 13C NMR, FTIR, and HRMS. Synthesized ...
Application of magnetic solid‑phase extraction for sensitive determination of anticancer drugs in urine by means of diamino benzidine tetrachlorohydrate modified magnetic nanoparticles
(Springer, 25 Februar)
Background The analysis of drug active molecules and residues in the treatment of cancer is important for the sustainability of
human life and therapeutic effects. For this purpose, a new magnetic sorbent was developed ...
Use of newly synthetized magnetic Fe3O4 nanoparticles modified with hexadecyl trimethyl ammonium bromide for the sensitive analysis of antidepressant drugs, duloxetine and vilazodone in wastewater and urine samples
(2023)
A new enrichment and determination method involving HPLC-DAD analysis following magnetic solidphase
extraction (MSPE) was developed to detect trace amounts of two antidepressant drugs, namely,
duloxetine (DUL) and ...
Propolis nanoparticles synthesis and characterization with cytotoxic and apoptotic effects on breast cancer cells
(2023)
The aim of this work was to investigate the antiproliferative and pro-apoptotic effects of propolis
on human breast cancer cells using a simple and inexpensive nanoformulation. Various meth ods were used to characterize ...