| dc.description.abstract | The aim of this study was to investigate the teratogenic effects of Malathion (ML) induced by different doses on fetal kidney tissues in pregnant rats. A total of 28 Sprague-Dawley pregnant rats were randomly divided into 4 groups of 7 rats each. Depending on ML dose, four groups were formed, including (I) control, (II) ML 2.5 (ML 2.5 mg/kg/day, orally), (III) ML 5 (5 mg/kg/day, orally), and (IV) ML 10 (10 mg/kg/day, orally). ML application started when the male and female were put together (when mating started). Daily ML application was continued until birth. It was determined that in parallel with dose of ML, ML resulted in toxic effects on serum enzymes (acetyl-cholinesterase (AChE), amylase and lipase) and kidney tissues of pregnant rats, and also -regardless of ML dose in fetal kidneys- it led to teratogenic effects in all the doses. Biochemical data wasconfirmed by histopathologic data. We concluded that ML leads to kidney damage in both pregnant and fetal rats as a result of its teratogenic and toxic effects. | en_US |
| dc.contributor.department | Alp, H., Mustafa Kemal University, Medical Faculty, Department of Pharmacology, TR-31040 Hatay, Turkey -- Sak, M.E., Dicle University, Medical Faculty, Department of obstetrics and gynecology, TR-21280 Diyarbakir, Turkey -- Evsen, M.S., Dicle University, Medical Faculty, Department of obstetrics and gynecology, TR-21280 Diyarbakir, Turkey -- Firat, U., Dicle University, Medical Faculty, Department of Pathology, TR-21280 Diyarbakir, Turkey -- Evliyaoglu, O., Dicle University, Medical Faculty, Department of Biochemistry, Diyarbakir, Turkey -- Penbegul, N., Dicle University, Medical Faculty, Department of Urology, TR-21280 Diyarbakir, Turkey -- Sancaktutar, A.A., Dicle University, Medical Faculty, Department of Urology, TR-21280 Diyarbakir, Turkey -- Soylemez, H., Dicle University, Medical Faculty, Department of Urology, TR-21280 Diyarbakir, Turkey -- Tuzcu, M., Cumhuriyet University, Veterinary Faculty, Department of Pathology, TR-58140 Sivas, Turkey | en_US |
