dc.contributor.author | Korkmaz S. | |
dc.contributor.author | Demirkan B. | |
dc.contributor.author | Altay H. | |
dc.contributor.author | Ege M.R. | |
dc.contributor.author | Çaldir V. | |
dc.contributor.author | Yilmaz M.B. | |
dc.contributor.author | Güray Y. | |
dc.contributor.author | Güray U. | |
dc.contributor.author | Şaşmaz H. | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:15:03Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:15:03Z | |
dc.date.issued | 2011 | |
dc.identifier.issn | 1302-8723 | |
dc.identifier.uri | https://dx.doi.org/10.5152/akd.2011.107 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/5026 | |
dc.description.abstract | Objective: Renal dysfunction has been shown to be linked to high risk for cardiovascular events. Even milder forms of creatinine elevation are associated with poor cardiovascular outcomes. We designed a retrospective study and searched the association of angiographic extent of coronary artery disease and creatinine levels in patients without overt renal dysfunction. Methods: We retrospectively reviewed 892 consecutive patients with typical stable angina pectoris (311 female with mean age of 62±10 years, 581 male with mean age of 56±11 years) at Türkiye Yüksek İhtisas Hospital and creatinine level ?3 mg/dl without history of hemodialysis. Patients without overt renal disease were divided into 3 groups according to level of creatinine (Group A: Cr level <1.2 mg/dl, Group B: Cr level ?1.2 and <1.5 mg/dl and Group C: Cr level ?1.5 -?3 mg/dl). Additionally after evaluation of coronary angiograms, patients were also classified according to those with high stenosis (stenosis score ?16) and high extension scores (extension score >50%) versus low stenosis and low extension scores. Logistic regression analysis was performed to establish the clinical predictors of high total stenosis and high extension scores. Results: Each group of patients according to level of creatinine showed marked difference in terms of angiographic extent of coronary artery disease (p<0.001). Those in the highest creatinine group (?1.5 mg/dl, but not above 3 mg/dl) had the highest total stenosis (17±6, p<0.001) and extension (78±25, p<0.001) scores irrespective of age and gender. Creatinine was shown to be significantly correlated with both stenosis and extension scores. Age (OR:1.035, 95% CI:1.016-1.054, p<0.0001), being male (OR:1.746, 95% CI: 1.135-2.685, p=0.011), presence of hypertension (OR:1.507, 95%CI: 1.005-2.25 p=0.047), presence of diabetes mellitus (OR: 1.865, 95%: 1.250-2.783, p=0.002), previous history of myocardial infarction (OR: 1.624, 95%CI: 1.094-2.413, p=0.016), wall motion score index (OR:1.203, 95%CI: 1.108-1.305, p<0.0001) and creatinine (OR:4.037, 95%CI: 2.530-6.443, p<0.0001) level were found to be independent predictors of high total stenosis score. Furthermore, age (OR:1.042, 95%CI: 1.026-1.059, p<0.0001), being male (OR:2.587, 95%CI: 1.794-3.731, p<0.0001), presence of hypertension (OR:1.536, 95% CI:1.100-2.147, p=0.012), previous myocardial infarction (OR:6.183, 95%CI: 4.340-8.807, p<0.0001), total cholesterol/HDL ratio (OR:1.215, 95%CI: 1.114-1.327, p<0.0001) and creatinine (OR:3.814, 95%CI: 2.149-6.768, p<0.0001) were found to be independent predictors of high extension score. Conclusion: Serum creatinine seems to denote severity of angiographic extent of coronary artery disease in patients with typical chest pain. (Anadolu Kardiyol Derg 2011; 11: 407-13) © Telif Hakk{dotless}2011 AVES Yay{dotless}nc{dotless}li{dotless}k Ltd. | en_US |
dc.description.sponsorship | Demirkan, B.; Department of Cardiology, Türkiye Yüksek Ihtisas Hospital, Ankara, Turkey; email: burcume@gmail.com | en_US |
dc.language.iso | eng | en_US |
dc.relation.isversionof | 10.5152/akd.2011.107 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Coronary artery disease | en_US |
dc.subject | Creatinine | en_US |
dc.subject | Extension | en_US |
dc.subject | Logistic regression analysis | en_US |
dc.subject | Mild renal dysfunction | en_US |
dc.title | Serum creatinine is independently associated with angiographic extent of coronary artery disease in patients with stable angina pectoris [Kararli{dotless} anjina pektorisli hastalarda serum kreatinini ba?i{dotless}msi{dotless}z olarak koroner arter hastali{dotless}?i{dotless}ni{dotless}n anjiyografik yaygi{dotless}nli{dotless}?i{dotless} ile ilişkilidir] | en_US |
dc.type | review | en_US |
dc.relation.journal | Anadolu Kardiyoloji Dergisi | en_US |
dc.contributor.department | Korkmaz, S., Clinic of Cardiology, Türkiye Yüksek Ihtisas Hospital, Ankara, Turkey -- Demirkan, B., Clinic of Cardiology, Türkiye Yüksek Ihtisas Hospital, Ankara, Turkey -- Altay, H., Department of Cardiology, Başkent University, Adana Teaching and Research Hospital, Adana, Turkey -- Ege, M.R., Clinic of Cardiology, Yalova State Hospital, Yalova, Turkey -- Çaldir, V., Department of Cardiology, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey -- Yilmaz, M.B., Clinic of Cardiology, Türkiye Yüksek Ihtisas Hospital, Ankara, Turkey -- Güray, Y., Clinic of Cardiology, Türkiye Yüksek Ihtisas Hospital, Ankara, Turkey -- Güray, U., Clinic of Cardiology, Türkiye Yüksek Ihtisas Hospital, Ankara, Turkey -- Şaşmaz, H., Clinic of Cardiology, Türkiye Yüksek Ihtisas Hospital, Ankara, Turkey | en_US |
dc.identifier.volume | 11 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.endpage | 413 | en_US |
dc.identifier.startpage | 407 | en_US |
dc.relation.publicationcategory | Diğer | en_US |