dc.contributor.author | Karakuş G. | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:31:51Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:31:51Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 1309-0801 | |
dc.identifier.uri | https://dx.doi.org/10.12991/mpj.20151910458 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/5373 | |
dc.description | Marmara University | en_US |
dc.description.abstract | Poly(maleic anhydride-co-styrene) (MAST), poly(maleic anhydride-co-vinyl acetate) (MAVA), poly(maleic anhydride-co-methyl methacrylate) (MAMMA), poly(maleic anhydride-co-allyl phenyl ether) (MAAFE) and poly(maleic anhydride-alt-acrylic acid) (MAAA) copolymers were synthesized by free radical chain polymerization reaction. Modification/derivatization of the copolymers with active pharmaceutical ingredients, in amine form (-NH2), was performed by the ring opening reaction. Structural characterization of the copolymers and the conjugated products was carried out by Fourier Transform Infrared (FTIR) and Nuclear Magnetic Resonance (1H-NMR). The FTIR and 1H-NMR spectra, confirmed that pharmaceutically active agents were covalently bonded to the MAVA copolymer in a succesfull manner. Furthermore cytotoxicity on healthy fibroblast cell lines, antiproliferative activity on cancer cell lines and antibacterial activity on bacterial strains were also investigated in-vitro for synthesized conjugates. MAVA copolymer was also selected the most suitable carrier for modification/derivaritization process by comparing its affinity to the pharmaceutically active agents. © 2015, Marmara University. All rights reserved. | en_US |
dc.description.sponsorship | Karakuş, G.; Cumhuriyet Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim DalıTurkey | en_US |
dc.language.iso | tur | en_US |
dc.relation.isversionof | 10.12991/mpj.20151910458 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Antibacterial activity | en_US |
dc.subject | Antiproliferative activity | en_US |
dc.subject | Copolymer modification | en_US |
dc.subject | Ring opening reaction | en_US |
dc.subject | Structural characterization | en_US |
dc.title | Derivatization of some maleic anhydride containing copolymers with amine functionalized pharmaceutical active substances, structural characterizations and biological activities [Bazı maleik anhidrit İçeren kopolimerlerin amin yapılı İlaç etken maddeleri İle türevlendirilmesi, yapısal karakterizasyonu ve biyolojik aktiviteleri] | en_US |
dc.type | article | en_US |
dc.relation.journal | Marmara Pharmaceutical Journal | en_US |
dc.contributor.department | Karakuş, G., Cumhuriyet Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı, Sivas, 58140, Turkey | en_US |
dc.identifier.volume | 19 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.endpage | 125 | en_US |
dc.identifier.startpage | 121 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |