dc.description.abstract | Objectives: Our aim was to determine whether there is a relationship between admission gamma-glutamyltransferase (GGT) and subsequent heart failure hospitalizations in patients with acute coronary syndrome. Study design: We selected 123 patients with newly diagnosed acute coronary syndrome of ejection fraction (EF) <45%. Patients were followed 15±10 months, and the relationship between admission GGT level and hospitalization because of heart failure during the follow-up was examined. Results: Twenty-three (18.7%) patients were hospitalized during the follow-up of 15±10 months. Receiver operating characteristic (ROC) curve analysis showed that the cut-off point of admission GGT related to predict hospitalization was 49 IU/L, with a sensitivity of 81.7% and specificity of 65.2%. Increased GGT >49 IU/L on admission, presence of hypertension and hyperlipidemia, left ventricular ejection fraction (LVEF), right ventricular dysfunction, moderate-to-severe mitral regurgitation, alanine aminotransferase level, and antiplatelet agent usage were found to have prognostic significance in univariate Cox proportional hazards analysis. In multivariate Cox proportional-hazards model, increased GGT >49 IU/L on admission (hazard ratio [HR] 2.663, p=0.047), presence of hypertension (HR 4.107, p=0.007), and LVEF (HR 0.911, p=0.002) were found to be independent factors to predict new-onset heart failure requiring hospitalization. Conclusion: Hospitalization in heart failure was associated with increased admission GGT levels. Increased admission GGT level in acute coronary syndrome with heart failure should be monitored closely and treated aggressively. © 2014 Turkish Society of Cardiology. | en_US |
dc.contributor.department | Sarikaya, S., Department of Cardiology, Bozok University, Cumhuriyet University, Yozgat, Turkey -- Aydin, G., Department of Cardiology, Cumhuriyet University, Faculty of Medicine, Sivas, Turkey -- Yuc?el, H., Department of Cardiology, Cumhuriyet University, Faculty of Medicine, Sivas, Turkey -- Kaya, H., Department of Cardiology, Cumhuriyet University, Faculty of Medicine, Sivas, Turkey -- Yildirimli, K., Department of Cardiology, Cumhuriyet University, Faculty of Medicine, Sivas, Turkey -- Basa?ran, A., Department of Cardiology, Cumhuriyet University, Faculty of Medicine, Sivas, Turkey -- Zorlu, A., Department of Cardiology, Cumhuriyet University, Faculty of Medicine, Sivas, Turkey -- Şahin, Ş., Department of Internal Medicine, Gaziosmanpaşa University, Faculty of Medicine, Tokat, Turkey -- Akyol, L., Department of Internal Medicine, Bozok University, Faculty of Medicine, Yozgat, Turkey -- Bulut, M., Department of Cardiology, Universal Malatya Hospital, Malatya, Turkey | en_US |