Brucellosis in pregnancy: results of multicenter ID-IRI study
Tarih
2019Yazar
Inan, AsumanErdem, Hakan
Elaldi, Nazif
Gulsun, Serda
Karahocagil, Mustafa K.
Pekok, Abdullah U.
Ulug, Mehmet
Tekin, Recep
Bosilkovski, Mile
Kaya, Safak
Haykir-Solay, Asli
Demirdal, Tuna
Kaya, Selcuk
Sunnetcioglu, Mahmut
Sener, Alper
Tosun, Selma
Aydin, Emsal
Ural, Serap
Yamazhan, Tansu
Muhcu, Murat
Ayaslioglu, Ergin
Bilgic-Atli, Seval
Erbay, Ayse
Ergen, Pinar
Kadanali, Ayten
Sahin, Suzan
Sahin-Horasan, Elif
Avci, Ali
Cag, Yakup
Beeching, Nicholas J.
Üst veri
Tüm öğe kaydını gösterÖzet
Brucellosis in pregnant women is reported to be associated with obstetric complications (OCs), and adequate data for human brucellosis during pregnancy are largely lacking. We performed this multicenter retrospective cross-sectional study to evaluate the epidemiology, clinical course, treatment responses, and outcomes of brucellosis among pregnant women. The study period comprised a 14-year period from January 2002 to December 2015. All consecutive pregnant women diagnosed with brucellosis in 23 participating hospitals were included. Epidemiological, clinical, laboratory, therapeutic, and outcome data along with the assessment data of the neonate were collected using a standardized questionnaire. Data of 242 patients were analyzed. The OC rate was 14.0% (34/242) in the cohort. Of the 242 women, 219 (90.5%) delivered at term, 3 (1.2%) had preterm delivery, 15 (6.2%) aborted, and 5 (2.1%) had intrauterine fetal demise. Seventeen (7.0%) of the newborns were considered as low birth weight. Spontaneous abortion (6.1%) was the commonest complication. There were no maternal or neonatal deaths and pertinent sequelae or complications were not detected in the newborns. Splenomegaly (p=0.019), nausea and/or vomiting (p<0.001), vaginal bleeding (p<0.001), anemia (blood hemoglobin <11g/dL; p<0.001), high level of serum aspartate aminotransferase (>41IU/L; p=0.025), oligohydramnios on ultrasonography (p=0.0002), history of taking medication other than Brucella treatment during pregnancy (p=0.027), and Brucella bacteremia (p=0.029) were the significant factors associated with OCs. We recommend that pregnant women with OC or with fever should be investigated for brucellosis if they live in or have traveled to an endemic area.
Kaynak
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASESCilt
38Sayı
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