dc.contributor.author | Atabey, Mustafa | |
dc.contributor.author | Tas, Ayca | |
dc.contributor.author | Sari, Ismail | |
dc.contributor.author | Bostanci, Meric Emre | |
dc.contributor.author | Topcu, Omer | |
dc.contributor.author | Silig, Yavuz | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:37:05Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:37:05Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 1107-0625 | |
dc.identifier.issn | 2241-6293 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/5909 | |
dc.description | WOS: 000471764000037 | en_US |
dc.description.abstract | Purpose: The Murine double minute 2 (MDM2) gene plays a crucial role in regulating and suppressing the function of apoptotic pathway. We investigated the relationship between MDM2 gene SNP309 (T309G) (rs2279744) polymorphism and colorectal cancer (CRC) in a Turkish population. Methods: The polymorphism T309G (rs2279744) in the MDM2 gene was studied in patients with colorectal cancer (n=135) and healthy control subjects (n=145) using the polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) method The findings were evaluated using logistic regression and x(2) tests. Results: When CRC cases and controls were evaluated based on different habits and family cancer histories, a statistically significant relationship was found between CRC and alcohol consumption (x(2) =4.07, p=0.044). Cancer cases and controls had statistically significant different family histories of cancer (x(2) =6.82, p =0.009). There was also significant difference in TG genotype distribution in the MDM2 T309G polymorphism between those with and without cancer (OR=1.98, 95% CI =1.98-3.91, x(2) =4.00, p =0.045). Conclusions: The SNP309 polymorphism of the MDM2 gene is associated with increased CRC risk in the Turkish population. | en_US |
dc.description.sponsorship | Cumhuriyet University [CUBAP T-547] | en_US |
dc.description.sponsorship | This research was supported by Cumhuriyet University via research grants provided to the project CUBAP T-547. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | IMPRIMATUR PUBLICATIONS | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | colorectal cancer | en_US |
dc.subject | polymorphism T309G (rs2279744) | en_US |
dc.subject | MDM2 gene | en_US |
dc.subject | Turkish population | en_US |
dc.title | Significant association between MDM2 T309G polymorphism and colorectal cancer | en_US |
dc.type | article | en_US |
dc.relation.journal | JOURNAL OF BUON | en_US |
dc.contributor.department | [Atabey, Mustafa] Medicana Sivas Hosp, Clin Gen Surg, Sivas, Turkey -- [Tas, Ayca] Cumhuriyet Univ, Fac Hlth Sci, Dept Nutr & Diet, Sivas, Turkey -- [Sari, Ismail] Omer Halis Demir Univ, Fac Med, Dept Biochem, Nigde, Turkey -- [Bostanci, Meric Emre -- Topcu, Omer] Cumhuriyet Univ, Fac Med, Dept Gen Surg, Sivas, Turkey -- [Silig, Yavuz] Cumhuriyet Univ, Fac Med, Dept Biochem, TR-58140 Sivas, Turkey | en_US |
dc.identifier.volume | 24 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.endpage | 1142 | en_US |
dc.identifier.startpage | 1137 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |