dc.contributor.author | Kozluca, Hatice | |
dc.contributor.author | Dural, Emrah | |
dc.contributor.author | Karabiyikoglu, Gulseren | |
dc.contributor.author | Soylemezoglu, Tulin | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:38:53Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:38:53Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 0494-1373 | |
dc.identifier.uri | https://dx.doi.org/10.5578/tt.66932 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/6431 | |
dc.description | WOS: 000455820300007 | en_US |
dc.description | PubMed ID: 30683027 | en_US |
dc.description.abstract | Introduction: Smoking is the leading cause of chronic obstructive pulmonary disease (COPD) and cotinine is reliable marker of tobacco exposure. We aimed to investigate the relationship between pulmonary function tests (FVC%, FEV1 , FEV1/FVC and FEF25-75%), smoking history and blood cotinine levels in healthy volunteers as a control and patients who have COPD in our study. Materials and Methods: One hundred and two COPD patients and 106 healthy volunteers who admitted to our institution were included. Spirometric investigations of the patients and volunteers were performed. A simple, rapid and reliable gas chromatography-mass spectrometry (GC-MS) method was used for determination of cotinine levels in blood samples. Results: The cut-off value of cotinine was determined as 41.12 ng/mL (97.2% sensitivity and 100% specificity). A significant relationship was observed between average pack-year and cotinine level in current smoker group (p< 0.05). The mean cotinine levels were 6.1, 8.8, and 467.0 ng mL(-1) in never smokers, ex-smokers and current smokers, respectively. No relationship was observed between cotinine level and FVC%, FEV1 % and FEV1/FVC (p> 0.05). In patient group, there was also no relationship between FEF25-75% and cotinine level however, in control group-smokers a negative correlation was found (p< 0.05; r= -0.372). Conclusion: We observed once again with our study that cotinine is a reliable marker of tobacco exposure. The most obvious result is the negative correlation between FEF25-75% value and cotinine level and this result may be caused by the effect of smoking in the peripheral airways at early stages of COPD. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | TURKISH ASSOC TUBERCULOSIS & THORAX | en_US |
dc.relation.isversionof | 10.5578/tt.66932 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Cotinine | en_US |
dc.subject | chronic obstructive pulmonary diseases (COPD) | en_US |
dc.subject | cigarette | en_US |
dc.subject | spirometry | en_US |
dc.subject | gas chromatography-mass spectrometry (GC-MS) | en_US |
dc.title | Pulmonary functional parameters and blood cotinine level in chronic obstructive pulmonary disease | en_US |
dc.type | article | en_US |
dc.relation.journal | TUBERKULOZ VE TORAK-TUBERCULOSIS AND THORAX | en_US |
dc.contributor.department | [Kozluca, Hatice -- Karabiyikoglu, Gulseren] Ankara Univ, Dept Chest Dis, Fac Med, Ankara, Turkey -- [Dural, Emrah -- Soylemezoglu, Tulin] Ankara Univ, Inst Forens Sci, Dept Forens Toxicol, Ankara, Turkey -- [Dural, Emrah] Sivas Cumhuriyet Univ, Dept Pharmaceut Toxicol, Fac Pharm, Sivas, Turkey | en_US |
dc.identifier.volume | 66 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.endpage | 324 | en_US |
dc.identifier.startpage | 317 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |