dc.contributor.author | Sari, Ismail | |
dc.contributor.author | Pinarbasi, Hatice | |
dc.contributor.author | Pinarbasi, Ergun | |
dc.contributor.author | Yildiz, Caglar | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:44:09Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:44:09Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 1064-1955 | |
dc.identifier.issn | 1525-6065 | |
dc.identifier.uri | https://dx.doi.org/10.1080/10641955.2017.1388390 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/6942 | |
dc.description | WOS: 000418577600006 | en_US |
dc.description | PubMed ID: 29058492 | en_US |
dc.description.abstract | Objective: In this study the association between K55R polymorphism, methylation level of the EPHX2 promoter region, and PE was investigated in 520 individuals including 260 PE patients and 260 healthy pregnant women.Methods: K55R polymorphism and methylation level of the EPHX2 promoter were determined by the real-time PCR using double-dye hydrolysis probes and methylation-sensitive high-resolution melting analysis, respectively.Results: The presence of the K55R polymorphism was significantly higher in cases (28.1%) than controls (17.3%), and was associated with increased risk of PE (OR: 1.86; 95% CI: 1.09-2.63). Methylation levels of the EPHX2 promoter region in cases were significantly lower than controls. A 2.83 times increased PE risk was observed in pregnant women with EPHX2 promoter methylation levels of <25% (OR: 2.83; 95% CI: 1.15-6.91).Conclusion: In conclusion, hypomethylation of the promoter region of EPHX2 and K55R polymorphism were associated with significant increased risk of PE. sEH enzyme may play a role in the pathogenesis of PE by contributing to reduction of the vasodilatator, anti-hypertensive, and anti-inflammatory effects of EETs by rapid degradation of these molecules. | en_US |
dc.description.sponsorship | Scientific Research Project Fund of Cumhuriyet University [T-551] | en_US |
dc.description.sponsorship | This work was supported by the Scientific Research Project Fund of Cumhuriyet University (grant number T-551). | en_US |
dc.language.iso | eng | en_US |
dc.publisher | TAYLOR & FRANCIS INC | en_US |
dc.relation.isversionof | 10.1080/10641955.2017.1388390 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Soluble epoxide hydrolase | en_US |
dc.subject | genetic polymorphism | en_US |
dc.subject | epoxyeicosatrienoic acid | en_US |
dc.subject | methylation | en_US |
dc.title | Association between the soluble epoxide hydrolase gene and preeclampsia | en_US |
dc.type | article | en_US |
dc.relation.journal | HYPERTENSION IN PREGNANCY | en_US |
dc.contributor.department | [Sari, Ismail] Nigde Omer Halisdemir Univ, Sch Med, Dept Med Biochem, Nigde, Turkey -- [Pinarbasi, Hatice] Cumhuriyet Univ, Sch Med, Dept Biochem, TR-58140 Sivas, Turkey -- [Pinarbasi, Ergun] Cumhuriyet Univ, Sch Med, Dept Med Biol, Sivas, Turkey -- [Yildiz, Caglar] Cumhuriyet Univ, Sch Med, Dept Gynecol & Obstet, Sivas, Turkey | en_US |
dc.contributor.authorID | Sari, Ismail -- 0000-0003-3732-2102 | en_US |
dc.identifier.volume | 36 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.endpage | 325 | en_US |
dc.identifier.startpage | 315 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |