Epidemiology of Pemphigus in Turkey: One-year Prospective Study of 220 Cases
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Date
2017Author
Yayli, SavasHarman, Mehmet
Baskan, Emel Bulbul
Karakas, Ayse Akman
Genc, Yeser
Turk, Bengu Gerceker
Demirsoy, Evren Odyakmaz
Gunasti, Suhan
Bilgili, Serap Gunes
Ilter, Nilsel
Ferahbas, Ayten
Savk, Ekin
Afsar, Fatma Sule
Aytekin, Sema
Kaya, Tamer Irfan
Hayta, Sibel Berksoy
Ozgen, Zuleyha
Gurel, Mehmet Salih
Caliskan, Ercan
Balci, Didem Didar
Gungor, Sule
Kapicioglu, Yelda
Ozuguz, Pinar
Aktan, Sebnem
Dogramaci, Asena
Kokcam, Ibrahim
Onsun, Nahide
Seckin, Deniz
Durdu, Murat
Dursun, Recep
Daye, Munise
Dilek, Nursel
Karabacak, Ercan
Temel, Asli Bilgic
Erdem, Cengizhan
Altun, Ece
Gungor, Dilek
Kartal, Demet
Akyol, Melih
Aksu, Esra Koku
Uzun, Soner
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Show full item recordAbstract
Pemphigus is a group of rare and life-threatening autoimmune blistering diseases of the skin and mucous membranes. Although they occur worldwide, their incidence shows wide geographical variation, and prospective data on the epidemiology of pemphigus are very limited. Objective of this work is to evaluate the incidence and epidemiological and clinical features of patients with pemphigus in Turkey. All patients newly diagnosed with pemphigus between June 2013 and June 2014 were prospectively enrolled in 33 dermatology departments in 20 different provinces from all seven regions of Turkey. Disease parameters including demography and clinical findings were recorded. A total of 220 patients were diagnosed with pemphigus during the 1-year period, with an annual incidence of 4.7 per million people in Turkey. Patients were predominantly women, with a male to female ratio of 1:1.41. The mean age at onset was 48.9 years. Pemphigus vulgaris (PV) was the commonest clinical subtype (n= 192; 87.3%), followed by pemphigus foliaceus (n= 21; 9.6%). The most common clinical subtype of PV was the mucocutaneous type (n= 83; 43.2%). The mean Pemphigus Disease Area Index was 28.14 +/- 22.21 (mean +/- Standard Deviation). The incidence rate of pemphigus in Turkey is similar to the countries of South-East Europe, higher than those reported for the Central and Northern European countries and lower than the countries around the Mediterranean Sea and Iran. Pemphigus is more frequent in middle-aged people and is more common in women. The most frequent subtype was PV, with a 9-fold higher incidence than pemphigus foliaceus.
Source
ACTA DERMATOVENEROLOGICA CROATICAVolume
25Issue
3Collections
- Makale Koleksiyonu [5200]
- Makale Koleksiyonu [5745]
- Öksüz Yayınlar Koleksiyonu - WoS [6162]