dc.contributor.author | Kose, Muhammet | |
dc.contributor.author | Hepokur, Ceylan | |
dc.contributor.author | Karakas, Duran | |
dc.contributor.author | McKee, Vickie | |
dc.contributor.author | Kurtoglu, Mukerrem | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:44:38Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:44:38Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 0277-5387 | |
dc.identifier.uri | https://dx.doi.org/10.1016/j.poly.2016.07.007 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/7129 | |
dc.description | WOS: 000384384500078 | en_US |
dc.description.abstract | In this study, two new copper(II) complexes, [Cu(L-1)(2)](ClO4)(2) and [Cu(L-2)(2)](ClO4)(2) derived from dicyandiamide were synthesized and characterized by the analytical and spectroscopic methods such as elemental analyses, infrared and mass, spectra. The ligands L-1 and L-2 formed within the course of the complex formation by nucleophilic attach of alcohols to the nitrile group of the ligand in the presence of Cu(II) ion. In the spectra of the complexes, the absence of the v(C N) band at ca. 2157 cm(-1) and appearance of new bands characteristic of v(a)(C-O-C) at ca. 1265 crn(-1) suggested that the alcohols have added across the nitrile group of the ligand. This was further confirmed by single crystal X-ray analysis of the complexes. In the structure of the complexes, copper(II) ion has square planar geometry, coordinated to the imine nitrogen atom with no significant interactions above or below the plane. The coordinated nitrogen donors show convincing imine (C=N) bond character. Computational studies are performed on [Cu (L-1)(2)](ClO4)(2) and [Cu(L-2)(2)](ClO4)(2) complexes. Optimized geometries, frontier molecular orbitals (FMO) and non-linear optical (NLO) properties of the complexes were studied. Cytotoxic effects of the synthesized copper(II) complexes at various concentrations were also studied against 3 different cell lines, mouse connective tissue fibroblast (L929), breast cancer (MCF-7) and bone cancer (MG63). (C) 2016 Elsevier Ltd. All rights reserved. | en_US |
dc.description.sponsorship | Council of Higher Education (Turkey); office of scientific research projects of Cumhuriyet University [F-372] | en_US |
dc.description.sponsorship | The authors also thank to Council of Higher Education (Turkey) for financial support. The authors are grateful to the Department of Chemistry, Loughborough University for providing laboratory and analytical facilities. We are also grateful the office of scientific research projects of Cumhuriyet University (Projects No: F-372) for financial supports. Gaussian calculations in this paper are performed at TUBITAK ULAKBIM, High Performance and Grid Computing Center (TRUBA Resources). | en_US |
dc.language.iso | eng | en_US |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | en_US |
dc.relation.isversionof | 10.1016/j.poly.2016.07.007 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Dicyandiamide | en_US |
dc.subject | Cu(II) complex | en_US |
dc.subject | Crystal structure | en_US |
dc.subject | Computational studies | en_US |
dc.subject | Anticancer activity | en_US |
dc.title | Structural, computational and cytotoxic studies of square planar copper(II) complexes derived from dicyandiamide | en_US |
dc.type | article | en_US |
dc.relation.journal | POLYHEDRON | en_US |
dc.contributor.department | [Kose, Muhammet -- Kurtoglu, Mukerrem] Kahramanmaras Sutcu Imam Univ, Dept Chem, TR-46050 Kahramanmaras, Turkey -- [Hepokur, Ceylan] Cumhuriyet Univ, Dept Biochem, Fac Pharm, TR-58140 Sivas, Turkey -- [Karakas, Duran] Cumhuriyet Univ, Dept Chem, TR-58140 Sivas, Turkey -- [McKee, Vickie] Dublin City Univ, Sch Chem Sci, Dublin 9, Ireland | en_US |
dc.contributor.authorID | Kose, Muhammet -- 0000-0002-4597-0858; McKee, Vickie -- 0000-0002-7780-5814 | en_US |
dc.identifier.volume | 117 | en_US |
dc.identifier.endpage | 660 | en_US |
dc.identifier.startpage | 652 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |