dc.contributor.author | Genc, Hayriye | |
dc.contributor.author | Kalin, Ramazan | |
dc.contributor.author | Koksal, Zeynep | |
dc.contributor.author | Sadeghian, Nastaran | |
dc.contributor.author | Kocyigit, Umit M. | |
dc.contributor.author | Zengin, Mustafa | |
dc.contributor.author | Gulcin, Ilhami | |
dc.contributor.author | Ozdemir, Hasan | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:44:41Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:44:41Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 1422-0067 | |
dc.identifier.uri | https://dx.doi.org/10.3390/ijms17101736 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/7143 | |
dc.description | WOS: 000387768300031 | en_US |
dc.description.abstract | beta-Lactams are pharmacologically important compounds because of their various biological uses, including antibiotic and so on. beta-Lactams were synthesized from benzylidene-inden derivatives and acetoxyacetyl chloride. The inhibitory effect of these compounds was examined for human carbonic anhydrase I and II (hCA I, and II) and acetylcholinesterase (AChE). The results reveal that beta-lactams are inhibitors of hCA I, II and AChE. The Ki values of beta-lactams (2a-k) were 0.44-6.29 nM against hCA I, 0.93-8.34 nM against hCA II, and 0.25-1.13 nM against AChE. Our findings indicate that beta-lactams (2a-k) inhibit both carbonic anhydrases (CA) isoenzymes and AChE at low nanomolar concentrations. | en_US |
dc.description.sponsorship | Sakarya University [BAPK-2012-02-04-031] | en_US |
dc.description.sponsorship | We gratefully acknowledge the partial financial support for this research project from Sakarya University BAPK-2012-02-04-031. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | MDPI | en_US |
dc.relation.isversionof | 10.3390/ijms17101736 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | carbonic anhydrase | en_US |
dc.subject | acetylcholinesterase | en_US |
dc.subject | beta-lactam | en_US |
dc.subject | 2-azetidinone | en_US |
dc.subject | enzyme inhibition | en_US |
dc.subject | enzyme purification | en_US |
dc.title | Discovery of Potent Carbonic Anhydrase and Acetylcholinesterase Inhibitors: 2-Aminoindan beta-Lactam Derivatives | en_US |
dc.type | article | en_US |
dc.relation.journal | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | en_US |
dc.contributor.department | [Genc, Hayriye -- Zengin, Mustafa] Sakarya Univ, Fac Arts & Sci, Dept Chem, TR-54050 Sakarya, Turkey -- [Kalin, Ramazan] Erzurum Tech Univ, Dept Basic Sci, Fac Sci, TR-25700 Erzurum, Turkey -- [Koksal, Zeynep] Istanbul Medeniyet Univ, Dept Chem, Fac Sci, TR-34730 Istanbul, Turkey -- [Sadeghian, Nastaran -- Gulcin, Ilhami] Ataturk Univ, Dept Chem, Fac Sci, TR-25240 Erzurum, Turkey -- [Kocyigit, Umit M.] Cumhuriyet Univ, Vocat Sch Hlth Serv, TR-58140 Sivas, Turkey -- [Gulcin, Ilhami] King Saud Univ, Dept Zool, Coll Sci, Riyadh 11451, Saudi Arabia | en_US |
dc.contributor.authorID | GULCIN, Ilhami -- 0000-0001-5993-1668; | en_US |
dc.identifier.volume | 17 | en_US |
dc.identifier.issue | 10 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |